Sarcoma Preoperative Radiation With Simultaneous INTegrated Boost (SPRINT)

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Intervention prospective monocentric one arm study on the use of neoadjuvant radiotherapy with simultaneous integrated boost (Simultaneous Integrated Boost, SIB) in patients with STS with indication for preoperative radiotherapy. The treatment will be administered in 25 daily fractions (Monday-Friday) at the disease site to include the region of suspected micrometastatic spread (Clinical Target Volume 1, CTV1) at a dose of 50 Gy (2Gy / fraction) with SIB intensification on volume reduced corresponding to the interface sites between the tumor and the vascular / nerve axes (Clinical Target Volume 2, CTV2) at a dose of 60 Gy (2.4 Gy / fraction). The association with neoadjuvant chemotherapy based on anthracyclines is allowed.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients aged ≥ 18 years

• Confirmed histological diagnosis of soft tissue sarcoma

• Candidate for conservative surgery

• Performance status ≤ 1 according to WHO (or ≥ 70 according to KPS) before starting the treatment in the office.

Locations
Other Locations
Italy
AOU Careggi
RECRUITING
Florence
Contact Information
Primary
Marta Pacinico
marta.pacinico@unifi.it
0557947192
Time Frame
Start Date: 2022-07-19
Estimated Completion Date: 2027-07-01
Participants
Target number of participants: 33
Treatments
Experimental: A
Related Therapeutic Areas
Adult Soft Tissue Sarcoma
Sponsors
Leads: Azienda Ospedaliero-Universitaria Careggi

This content was sourced from clinicaltrials.gov

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