Circulating Tumor DNA Detection in Soft Tissue Sarcoma (DNA-TSAR)
This research study will collect blood and tumor tissue samples from patients with soft tissue sarcoma to look at circulating tumor deoxyribonucleic acid (DNA). When tumor cells are damaged or die, DNA from the tumor cells are released into the blood stream as the cells break down. This is called circulating tumor DNA. Circulating tumor DNA is an important biomarker that may be used in cancer detection, prediction of treatment response, and disease monitoring.
• Patients must have histologically confirmed high-risk extremity or retroperitoneal liposarcoma, leiomyosarcoma and undifferentiated pleomorphic sarcoma.
• Patients must have archival tissue from the diagnostic biopsy available.
• Deemed appropriate for preoperative or postoperative radiotherapy and curative surgery following patient assessment by radiation oncologist and surgical oncologist.
• Age 18 years or older.
• Eastern Cooperative Group (ECOG) performance status ≤ 2
• Ability to understand and willing to sign a written informed consent document and comply with study requirements.