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Defining Retinal Structures Using Hyperspectral Retinal Imaging

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study evaluates hyperspectral retinal imaging as a novel, non-invasive imaging technique to characterise retinal and optic nerve structures in healthy individuals and patients with eye disease. Hyperspectral imaging captures retinal data across multiple wavelengths to generate detailed spectral information that may reveal features not visible with conventional retinal photography. Approximately 1000 participants will undergo multi-modal ophthalmic imaging in Melbourne, Australia, including hyperspectral imaging, OCT, fundus photography, and related tests. The study aims to compare hyperspectral imaging with standard imaging methods and assess its ability to identify retinal biomarkers associated with diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Adults aged 18 years and older

• Able to provide informed consent

• Willing and able to attend a study visit at the Centre for Eye Research Australia

• Participants with diagnosed retinal or optic nerve disease (e.g., diabetic retinopathy, glaucoma, age-related macular degeneration)

• Age- and sex-matched healthy control participants without known retinal or optic nerve disease

Locations
Other Locations
Australia
The Centre for Eye Research Australia
RECRUITING
Melbourne
Contact Information
Primary
Darvy Dang
darvy.dang@unimelb.edu.au
+61 3 9959 0102
Time Frame
Start Date: 2025-01-01
Estimated Completion Date: 2028-12-30
Participants
Target number of participants: 1000
Treatments
Experimental: Hyperspectral retinal imaging
Participants undergo non-invasive hyperspectral retinal imaging as part of a multi-modal ophthalmic imaging protocol. Hyperspectral imaging is performed using the Optina Diagnostics Metabolic Hyperspectral Retinal Camera and/or a prototype hyperspectral camera developed at the Centre for Eye Research Australia.~The intervention involves sequential retinal imaging across multiple wavelengths (\>25 spectral bands) following standard dilated fundus examination. Imaging is similar to conventional retinal photography but provides additional spectral information for each retinal pixel.~Participants also undergo standard clinical imaging (including OCT, OCT angiography, fundus photography, and autofluorescence) for comparison. The study is observational and non-therapeutic, with hyperspectral imaging used solely for research analysis of retinal structure and spectral biomarkers.
Related Therapeutic Areas
Ocular Hypertension (OHT)
Glaucoma
Diabetic Retinopathy
Late-Onset Retinal Degeneration
Age-Related Macular Degeneration (ARMD)
Sponsors
Leads: Center for Eye Research Australia

This content was sourced from clinicaltrials.gov

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