Learn About Agranulocytosis

What is the definition of Agranulocytosis?

White blood cells fight infections from bacteria, viruses, fungi, and other germs. One important type of white blood cell is the granulocyte, which is made in the bone marrow and travels in the blood throughout the body. Granulocytes sense infections, gather at sites of infection, and destroy the germs.

When the body has too few granulocytes, the condition is called agranulocytosis. This makes it harder for the body to fight off germs. As a result, the person may get sick from infections.

What are the alternative names for Agranulocytosis?

Granulocytopenia; Granulopenia; Neutropenia

What are the causes of Agranulocytosis?

Agranulocytosis may be caused by:

  • Autoimmune disorders
  • Bone marrow diseases, such as myelodysplasia or large granular lymphocyte (LGL) leukemia
  • Certain medicines used to treat diseases, including cancer
  • Certain street drugs
  • Poor nutrition
  • Preparation for bone marrow transplant
  • Benign familial neutropenia
  • Genetic variants, especially in people of certain African and Caribbean ethnicities
What are the symptoms of Agranulocytosis?

Symptoms of this condition may include:

  • Fever
  • Chills
  • Malaise
  • General weakness
  • Sore throat
  • Mouth and throat ulcers
  • Bone pain
  • Pneumonia
  • Shock
Not sure about your diagnosis?
Check Your Symptoms
What are the current treatments for Agranulocytosis?

Treatment depends on the cause of the low white blood cell count. For example, if a medicine is the cause, stopping or changing to another medicine may help. In other cases, medicines to help the body make more white blood cells will be used. If the cause is due to normal genes, no treatment is required.

Who are the top Agranulocytosis Local Doctors?
Hematology Oncology | Hematology | Oncology
Hematology Oncology | Hematology | Oncology

Central Washington Health Services Association

1201 S Miller St, 
Wenatchee, WA 
 33.2 mi
Accepting New Patients
Offers Telehealth

Julie Smith is a Hematologist Oncology specialist and a Hematologist in Wenatchee, Washington. Dr. Smith and is rated as an Advanced provider by MediFind in the treatment of Agranulocytosis. Her top areas of expertise are Paget Disease of the Breast, Breast Cancer, Familial Colorectal Cancer, and Familial Pancreatic Cancer. Dr. Smith is currently accepting new patients.

Hematology Oncology | Hematology | Oncology
Hematology Oncology | Hematology | Oncology

Central Washington Health Services Association

1201 S Miller St, 
Wenatchee, WA 
 33.2 mi
Accepting New Patients
Offers Telehealth

Mitchell Garrison is a Hematologist Oncology specialist and a Hematologist in Wenatchee, Washington. Dr. Garrison and is rated as an Advanced provider by MediFind in the treatment of Agranulocytosis. His top areas of expertise are Clear Cell Sarcoma, Familial Wilms Tumor 2, Renal Cell Carcinoma (RCC), and Chromophobe Renal Cell Carcinoma. Dr. Garrison is currently accepting new patients.

 
 
 
 
Learn about our expert tiers
Learn More
Hematology Oncology | Hematology | Oncology
Hematology Oncology | Hematology | Oncology

Central Washington Health Services Association

1201 S Miller St, 
Wenatchee, WA 
 33.2 mi
Accepting New Patients
Offers Telehealth

Lindsay Overton is a Hematologist Oncology specialist and a Hematologist in Wenatchee, Washington. Dr. Overton has been practicing medicine for over 17 years and is rated as an Advanced provider by MediFind in the treatment of Agranulocytosis. Her top areas of expertise are Primary Lymphoma of the Brain, Paget Disease of the Breast, Myelodysplastic Syndrome (MDS), and Pancreatoblastoma. Dr. Overton is currently accepting new patients.

What is the outlook (prognosis) for Agranulocytosis?

Treating or removing the cause often results in a good outcome.

How do I prevent Agranulocytosis?

If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests to monitor you.

What are the latest Agranulocytosis Clinical Trials?
A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections

Summary: The purpose of this study is to demonstrate the efficacy and evaluate the safety, and tolerability of mavorixafor in participants with congenital or acquired primary autoimmune and idiopathic chronic neutropenic disorders who are experiencing recurrent and/or serious infections as assessed by demonstrating its clinical benefit and increasing levels of circulating neutrophils.

Match to trials
Find the right clinical trials for you in under a minute
Get started
A Randomised, Phase 3 Trial Comparing 3-weekly Docetaxel 75 mg/m2 (in a 3 Week Cycle) Versus 2-weekly Docetaxel 50 mg/m2 (in a 4 Week Cycle) in Combination With Darolutamide + ADT in Patients With mHSPC

Summary: The purpose of this clinical phase 3 randomized trial is to compare two different dosing schedules of Docetaxel in combination with ADT and Darolutamide in subjects with mHSPC. The main question aims to compare grade 3-5 adverse events (AEs) in patients with mHSPC treated with 6 cycles of either Docetaxel 75 mg/m2 every 3 weeks in a 3 week cycle or 6 cycles of Docetaxel 50 mg/m2 every 2 weeks in a...

Who are the sources who wrote this article ?

Published Date: June 17, 2024
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Berliner N. Leukocytosis and leukopenia. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 153.

Klokkevold PR, Mealey BL, Hernandez-Kapila YL. Influence of systemic conditions on the periodontium. In: Newman MG, Klokkevold PR, Elangovan S, Hernandez-Kapila YL, eds. Newman and Carranza's Clinical Periodontology and Implantology. 14th ed. Philadelphia, PA: Elsevier; 2023:chap 25.

Murphy MF, Pasi KJ, Roy N. Haematology. In: Feather A, Randall D, Waterhouse M, eds. Kumar and Clark's Clinical Medicine. 10th ed. Philadelphia, PA: Elsevier; 2021:chap 16.

Rice L, Zieske AW, Jung M. Neutrophilic leukocytosis, neutropenia, monocytosis, and monocytopenia. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 49.