Learn About Agranulocytosis

What is the definition of Agranulocytosis?

White blood cells fight infections from bacteria, viruses, fungi, and other germs. One important type of white blood cell is the granulocyte, which is made in the bone marrow and travels in the blood throughout the body. Granulocytes sense infections, gather at sites of infection, and destroy the germs.

When the body has too few granulocytes, the condition is called agranulocytosis. This makes it harder for the body to fight off germs. As a result, the person is more likely to get sick from infections.

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What are the alternative names for Agranulocytosis?

Granulocytopenia; Granulopenia

What are the causes of Agranulocytosis?

Agranulocytosis may be caused by:

  • Autoimmune disorders
  • Bone marrow diseases, such as myelodysplasia or large granular lymphocyte (LGL) leukemia
  • Certain medicines used to treat diseases, including cancer
  • Certain street drugs
  • Poor nutrition
  • Preparation for bone marrow transplant
  • Problem with genes
What are the symptoms of Agranulocytosis?

Symptoms of this condition may include:

  • Fever
  • Chills
  • Malaise
  • General weakness
  • Sore throat
  • Mouth and throat ulcers
  • Bone pain
  • Pneumonia
  • Shock
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What are the current treatments for Agranulocytosis?

Treatment depends on the cause of the low white blood cell count. For example, if a medicine is the cause, stopping or changing to another medicine may help. In other cases, medicines to help the body make more white blood cells will be used.

Who are the top Agranulocytosis Local Doctors?
Elite
Highly rated in
11
conditions
Hematology Oncology

UW Medicine

General Internal Medicine Center At UWMC-Roosevelt

4245 Roosevelt Way Ne 
Seattle, WA 98105

David Dale is a Hematologist Oncology doctor in Seattle, Washington. Dr. Dale has been practicing medicine for over 56 years and is rated as an Elite doctor by MediFind in the treatment of Agranulocytosis. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Agranulocytosis, Chronic Familial Neutropenia, Cyclic Neutropenia, and Infantile Neutropenia. He is licensed to treat patients in Washington. Dr. Dale is currently accepting new patients.

Elite
Highly rated in
10
conditions

University Of Tübingen

Tuebingen, BW, DE 

Julia Skokowa is in Tuebingen, Germany. Skokowa is rated as an Elite expert by MediFind in the treatment of Agranulocytosis. She is also highly rated in 10 other conditions, according to our data. Her top areas of expertise are Agranulocytosis, Chronic Familial Neutropenia, Severe Congenital Neutropenia, and Cyclic Neutropenia.

 
 
 
 
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Elite
Highly rated in
15
conditions

University Children's Hospital Tübingen

Hannover, NI, DE 

Karl Welte is in Hannover, Germany. Welte is rated as an Elite expert by MediFind in the treatment of Agranulocytosis. He is also highly rated in 15 other conditions, according to our data. His top areas of expertise are Agranulocytosis, Chronic Familial Neutropenia, Severe Congenital Neutropenia, and Cyclic Neutropenia.

What is the outlook (prognosis) for Agranulocytosis?

Treating or removing the cause often results in a good outcome.

How do I prevent Agranulocytosis?

If you are having treatment or taking medicine that could cause agranulocytosis, your health care provider will use blood tests to monitor you.

Blood cells
What are the latest Agranulocytosis Clinical Trials?
CD34+ Stem Cell Selection for Patients Receiving a Matched or Partially Matched Family or Unrelated Adult Donor Allogeneic Stem Cell Transplantation for Non-Malignant Disease
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Host RNA Signature to Discriminate Bacterial From Viral Infection and Non-specific Inflammation in Children With Cancer
What are the Latest Advances for Agranulocytosis?
Retrospective Cohort Study of Clinical Efficacy and Safety of Cefozopran for Treating Febrile Neutropenia during Chemotherapy in Patients with Lung Cancer.
Phase II Study of S-1 and Irinotecan Plus Bevacizumab as Second-line Treatment for Patients With Metastatic Colorectal Cancer Resistant to the Fluoropyrimidine-oxaliplatin-cetuximab Regimen.
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A single-center retrospective analysis of 100 consecutive cases treated with lenalidomide/bortezomib/dexamethasone in newly diagnosed multiple myeloma.
Who are the sources who wrote this article ?

Published Date : May 27, 2020
Published By : Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Cook JR. Bone marrow failure syndromes. In: Hsi ED, ed. Hematopathology. 3rd ed. Philadelphia, PA: Elsevier; 2018:chap 5.

Klokkevold PR, Mealey BL. Influence of systemic conditions. In: Newman MG, Takei HH, Klokkevold PR, Carranza FA, eds. Newman and Carranza's Clinical Periodontology. 13th ed. Philadelphia, PA: Elsevier; 2019:chap 14.

Sive J, Foggo V. Haematological disease. In: Feather A, Randall D, Waterhouse M, eds. Kumar and Clarke's Clinical Medicine. 10th ed. Philadelphia, PA: Elsevier; 2021:chap 17.