Learn About Albright's Hereditary Osteodystrophy

What is the definition of Albright's Hereditary Osteodystrophy?
Albright's hereditary osteodystrophy (AHO) is a rare disorder with a wide range of signs and symptoms, including short stature, obesity, round face, subcutaneous ossifications (formation of bone under the skin), and short fingers and toes (brachydactyly). When the disorder is inherited from the mother, the features of AHO can be associated with resistance to certain hormones, in particular the parathyroid hormone (PTH). This is called pseudohypoparathyroidism type 1a (PHP1a). When inherited from the father, an individual will have AHO without any hormone issues, which is called pseudopseudohypoparathyroidism (PPHP). This condition is inherited in an autosomal dominant manner due to a genetic change in the GNAS gene.
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What are the alternative names for Albright's Hereditary Osteodystrophy?
  • Albright's hereditary osteodystrophy
  • Pseudohypoparathyroidism type 1A
  • Pseudopseudohypoparathyroidism
  • AHO
  • Albright hereditary osteodystrophy
  • Pseudohypoparathyroidism with Albright hereditary osteodystrophy
  • Albright hereditary osteodystrophy with multiple hormone resistance
  • PHP1A
  • Albright hereditary osteodystrophy without multiple hormone resistance
  • PPHP
  • Pseudo-Pseudohypoparathyroidism
  • Pseudopseudo-Hypoparathyroidism
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

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