Effect of Theophylline in Pseudohypoparathyroidism
Who is this study for? Patients with Pseudohypoparathyroidism
What treatments are being studied? Theophylline
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The study evaluates the effect of theophylline in 100 subjects with Pseudohypoparathyroidism.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 5
Maximum Age: 21
Healthy Volunteers: f
View:
• Subjects with known diagnosis of PHP1A and PHP1B
• Age \>5 years
Locations
United States
Massachusetts
Massachusetts General Hospital
RECRUITING
Boston
Contact Information
Primary
AMITA SHARMA, MD
asharma5@mgh.harvard.edu
6177262908
Time Frame
Start Date: 2019-11-11
Estimated Completion Date: 2032-04-10
Participants
Target number of participants: 100
Treatments
Experimental: Single arm open labeled intervention study
Subjects with PHP will be given theophylline to decrease the end organ resistance by increasing levels of cAMP, a second messenger. Theophylline will be dosed twice a day for a period of 52 weeks.
Related Therapeutic Areas
Sponsors
Leads: Massachusetts General Hospital