A Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Proof of Concept Study to Investigate Efficacy and Safety of LY4005130 in Adult Participants With Severe Alopecia Areata
Status: Recruiting
Location: See all (30) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The purpose of this study is to evaluate how well LY4005130 works in participants with severe alopecia areata (hair loss) when compared with placebo, and how well it's tolerated and what side effects may occur. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study drug will be administered intravenously (IV) (into a vein in the arm). The study will last approximately 48 weeks, including screening.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:
• Have severe Alopecia Areata (AA) that meets all of the following criteria:
‣ Hair loss encompassing ≥50% and ≤90% of the scalp, as measured by Severity of Alopecia Tool (SALT) score
⁃ The duration of the current episode of severe AA is at least 6 months and does not exceed 4 years
⁃ No significant spontaneous hair regrowth in the investigator's opinion for at least 6 months
⁃ Agree not to use any AA treatments during the study
Locations
United States
California
Center For Dermatology Clinical Research, Inc.
RECRUITING
Fremont
Northridge Clinical Trials
RECRUITING
Northridge
Cura Clinical Research - Santa Clarita - Kelly Johnson Parkway
RECRUITING
Santa Clarita
Florida
Health Clinical Research, LLC
RECRUITING
Cutler Bay
Massachusetts
Brigham and Women's Hospital
RECRUITING
Boston
Michigan
Revival Research Institute, LLC
RECRUITING
Troy
New Hampshire
Stracskin
RECRUITING
Portsmouth
Texas
Texas Dermatology and Laser Specialists - San Antonio - South New Braunfels Avenue
RECRUITING
San Antonio
Utah
Jordan Valley Dermatology & Research Center
RECRUITING
South Jordan
Other Locations
Canada
Kelowna Health and Memory Centre
RECRUITING
Kelowna
Ryan Clinical Research Inc.
RECRUITING
Newmarket
Dar Clinical Research - Ottawa - Hunt Club Road
RECRUITING
Ottawa
SIMa Recherche
NOT_YET_RECRUITING
Verdun
China
Beijing Friendship Hospital Affiliate of Capital University
NOT_YET_RECRUITING
Beijing
Huashan Hospital, Fudan University
RECRUITING
Shanghai
Shanghai Skin Disease Hospital
RECRUITING
Shanghai
Tianjin Medical University General Hospital
NOT_YET_RECRUITING
Tianjin
Netherlands
Erasmus Medisch Centrum
NOT_YET_RECRUITING
Rotterdam
Poland
Centrum Badan Klinicznych PI-House sp. z o.o.
RECRUITING
Gdansk
Diamond Clinic
RECRUITING
Krakow
Dermedic Jacek Zdybski
RECRUITING
Ostrowiec Świętokrzyski
Centrum Medyczne Ginemedica
RECRUITING
Wroclaw
Republic of Korea
Chung-Ang University Hospital
NOT_YET_RECRUITING
Dongjak-gu
Inha University Hospital
NOT_YET_RECRUITING
Incheon
Jeonbuk National University Hospital
NOT_YET_RECRUITING
Jeonju
Kyung Hee University Hospital at Gangdong
NOT_YET_RECRUITING
Seoul
Seoul National University Hospital
NOT_YET_RECRUITING
Seoul
United Kingdom
Chelsea and Westminster Hospital NHS Foundation Trust
NOT_YET_RECRUITING
London
Royal London Hospital
RECRUITING
London
Salford Royal Hospital
NOT_YET_RECRUITING
Salford
Contact Information
Primary
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
LillyTrials@Lilly.com
1-317-615-4559
Backup
Physicians interested in becoming principal investigators please contact