What is the definition of Alopecia Universalis?

Alopecia universalis (AU) is a condition characterized by the complete loss of hair on the scalp and body. It is an advanced form of alopecia areata, a condition that causes round patches of hair loss. Although the exact cause of AU is unknown, it is thought to be an autoimmune condition in which the person's immune system mistakenly attacks the hair follicles. An interaction between genetic and environmental factors is thought to play a role in the condition's onset. There is currently no cure for AU, but sometimes hair regrowth occurs on its own, even after many years.

What are the alternative names for Alopecia Universalis?

  • Alopecia areata universalis
  • AU

What are the causes for Alopecia Universalis?

The exact cause of AU is unknown. AU is an advanced form of alopecia areata (AA), a condition that leads to round patches of hair loss. The most widely accepted hypothesis is that AA is an autoimmune condition in which a person's immune system mistakenly attacks the hair follicles. While genetic studies have found that AA and AU are associated with several immune-related genes, they are likely ultimately caused by the interaction of multiple genetic and environmental factors. This means that even if someone inherits a genetic predisposition to the condition (susceptibility), they may not develop the condition unless something in the environment triggers its onset. However, the exact role of environmental factors is yet to be determined. Factors that may trigger the onset or recurrence of hair loss may include a viral infection, trauma, hormonal changes, and emotional or physical stress.

What are the symptoms for Alopecia Universalis?

AU is characterized by the complete loss of hair on both the scalp and body. Most people with AU do not have other signs and symptoms, but some may experience a burning or itching sensation. In some cases, AU can be associated with other conditions such as atopic dermatitis, thyroid disorders, and/or nail changes (such as pitting). Anxiety, personality disorders, depression, and paranoid disorders are more common in people with different forms of alopecia areata.

What are the current treatments for Alopecia Universalis?

No therapy has been found to work for everyone who has alopecia universalis (AU) which makes managing AU challenging. Although multiple treatments have been explored, no therapy is currently approved by the United States Food and Drug Administration (FDA). Some promising therapies include:
  • diphenylcyclopropenone (DPCP)
  • squaric acid dibutylester (SADBE)
  • photodynamic therapy
  • steroids
  • cyclosporine in combination with methylprednisolone (a steroid)

There are several recent studies showing that a class of medication known as JAK inhibitors, which includes Tofacitinib and Ruxolitinib, are effective in alopecia areata, including AU. However, JAK inhibitors have not yet been approved by the FDA for use in skin conditions. In some people with AU, hair regrowth occurs without treatment, sometimes after many years. There are steps that can be taken to decrease the chance of getting too much sun and minimize other discomforts related to having no hair. These may include:

  • Using sunscreen on the scalp, face, and all areas of the skin exposed to the sun
  • Wearing eyeglasses or sunglasses to protect the eyes from too much sun and from dust and debris when eyebrows or eyelashes are missing
  • Wearing wigs, caps, or scarves to protect the scalp from the sun and keep the head warm
  • Applying an ointment inside the nostrils to keep them moisturized and help to protect against organisms invading the nose when nostril hair is missing
Many other treatments have been reported to have variable response rates in small studies in alopecia areata. These include latanoprost, nitrogen mustard, massage and relaxation, isoprinosine, acupuncture, and aromatherapy, among others.

What is the outlook (prognosis) for Alopecia Universalis?

The course of AU is highly unpredictable, and this uncertainty is one of the most difficult and frustrating aspects of the disease. People with AU may continue to lose hair, or hair loss may stop. Hair that has already been lost may or may not grow back. It has been estimated that only about 10% of patients experience full recovery.

How is Alopecia Universalis diagnosed?

A diagnosis of AU is usually based on the signs and symptoms present. In rare cases, a scalp biopsy may be needed to confirm the diagnosis.

Is Alopecia Universalis an inherited disorder?

AU is believed to be a multifactorial condition, which means it is likely caused by a combination of environmental triggers and genetic predisposition (susceptibility). While a predisposition can be inherited and some people with AU have a family history, the condition itself is not thought to be inherited.
  • Condition: Alopecia areata
  • Journal: Dermatologic therapy
  • Treatment Used: Oral tofacitinib
  • Number of Patients: 9
  • Published —
The study reviewed the effects of oral tofacitinib on alopecia areata.
  • Condition: Alopecia areata
  • Journal: The Australasian journal of dermatology
  • Treatment Used: Whole body treatments
  • Number of Patients: 768
  • Published —
The study researched the outcomes of whole body (systemic) treatments for patients with alopecia areata.
Clinical Trial
  • Status: Active, not recruiting
  • Phase: Phase 2
  • Intervention Type: Drug
  • Participants: 70
  • Start Date: September 15, 2020
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Combination Product
  • Participants: 20
  • Start Date: October 30, 2021
Clinical Treatment of Alopecia Areata With Stem Cell Educator Therapy and Oral Minoxidil