Alpha-1 Antitrypsin Deficiency (AATD) Latest Advances

The mechanism of pathogenic α1-antitrypsin aggregation in the human liver.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: November 13, 2025

Pediatric Liver Diseases: Next-Generation Therapies.

Journal: Clinics in liver disease

Published: October 18, 2025

Pioglitazone reduces hepatic α-1 antitrypsin accumulation through autophagy and AMPK activation in α-1 antitrypsin-deficient mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology

Published: September 29, 2025

Pulmonary rehabilitation and quality of life in alpha-1 antitrypsin deficiency: findings from a retrospective cohort study.

Journal: Thorax

Published: September 18, 2025

Phenotypic Expression of Respiratory Diseases and Tailored Treatment in Patients with Intermediate Alpha-1 Antitrypsin Deficiency: Evidence from a Retrospective Analysis of a Selected Cohort of Patients.

Journal: Medicina (Kaunas, Lithuania)

Published: August 23, 2025

Applications of Artificial Intelligence in Alpha-1 Antitrypsin Deficiency: A Systematic Review from a Respiratory Medicine Perspective.

Journal: Medicina (Kaunas, Lithuania)

Published: August 12, 2025

Administrative coding for alpha-1 antitrypsin deficiency including the pi*ZZ phenotype is accurate in Sweden.

Journal: Scandinavian journal of gastroenterology

Published: August 11, 2025

Alpha-1 antitrypsin in COVID-19 patients: a dual-center screening study in Malaysia.

Journal: Annals of Saudi medicine

Published: August 03, 2025

A new SERPINA1 null allele of the PIS-plus type: PIQ0Tegueste.

Journal: Gene

Published: July 21, 2025

Distribution of SERPINA1 gene mutations in patients with spontaneous pneumothorax: A cross-sectional study from a tertiary chest diseases clinic in Turkiye.

Journal: Medicine

Published: July 14, 2025

Galectin-8 binding to alpha-1 antitrypsin is a physiological mechanism in healthy individuals but exacerbates the symptoms of alpha-1 antitrypsin deficiency.

Journal: Archives of biochemistry and biophysics

Published: June 27, 2025

Matrix metalloproteinases and disease severity among PIMZ and PIZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort.

Journal: BMJ open respiratory research

Published: June 26, 2025

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The mechanism of pathogenic α1-antitrypsin aggregation in the human liver.

The mechanism of pathogenic α1-antitrypsin aggregation in the human liver.

Pediatric Liver Diseases: Next-Generation Therapies.

Pediatric Liver Diseases: Next-Generation Therapies.

Pioglitazone reduces hepatic α-1 antitrypsin accumulation through autophagy and AMPK activation in α-1 antitrypsin-deficient mice.

Pioglitazone reduces hepatic α-1 antitrypsin accumulation through autophagy and AMPK activation in α-1 antitrypsin-deficient mice.

Pulmonary rehabilitation and quality of life in alpha-1 antitrypsin deficiency: findings from a retrospective cohort study.

Pulmonary rehabilitation and quality of life in alpha-1 antitrypsin deficiency: findings from a retrospective cohort study.

Phenotypic Expression of Respiratory Diseases and Tailored Treatment in Patients with Intermediate Alpha-1 Antitrypsin Deficiency: Evidence from a Retrospective Analysis of a Selected Cohort of Patients.

Phenotypic Expression of Respiratory Diseases and Tailored Treatment in Patients with Intermediate Alpha-1 Antitrypsin Deficiency: Evidence from a Retrospective Analysis of a Selected Cohort of Patients.

Applications of Artificial Intelligence in Alpha-1 Antitrypsin Deficiency: A Systematic Review from a Respiratory Medicine Perspective.

Applications of Artificial Intelligence in Alpha-1 Antitrypsin Deficiency: A Systematic Review from a Respiratory Medicine Perspective.

Administrative coding for alpha-1 antitrypsin deficiency including the pi*ZZ phenotype is accurate in Sweden.

Administrative coding for alpha-1 antitrypsin deficiency including the pi*ZZ phenotype is accurate in Sweden.

Alpha-1 antitrypsin in COVID-19 patients: a dual-center screening study in Malaysia.

Alpha-1 antitrypsin in COVID-19 patients: a dual-center screening study in Malaysia.

A new SERPINA1 null allele of the PI*S-plus type: PI*Q0Tegueste.

A new SERPINA1 null allele of the PI*S-plus type: PI*Q0Tegueste.

Distribution of SERPINA1 gene mutations in patients with spontaneous pneumothorax: A cross-sectional study from a tertiary chest diseases clinic in Turkiye.

Distribution of SERPINA1 gene mutations in patients with spontaneous pneumothorax: A cross-sectional study from a tertiary chest diseases clinic in Turkiye.

Galectin-8 binding to alpha-1 antitrypsin is a physiological mechanism in healthy individuals but exacerbates the symptoms of alpha-1 antitrypsin deficiency.

Galectin-8 binding to alpha-1 antitrypsin is a physiological mechanism in healthy individuals but exacerbates the symptoms of alpha-1 antitrypsin deficiency.

Matrix metalloproteinases and disease severity among PI*MZ and PI*ZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort.

Matrix metalloproteinases and disease severity among PI*MZ and PI*ZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort.

A new SERPINA1 null allele of the PIS-plus type: PIQ0Tegueste.

A new SERPINA1 null allele of the PIS-plus type: PIQ0Tegueste.

Matrix metalloproteinases and disease severity among PIMZ and PIZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort.

Matrix metalloproteinases and disease severity among PIMZ and PIZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort.