Condition 101 About Alternating Hemiplegia of Childhood

What is the definition of Alternating Hemiplegia of Childhood?

Alternating hemiplegia of childhood (AHC) is a neurological disorder that usually affects children before 18 months of age. Classic AHC causes recurrent episodes of paralysis (hemiplegia) that involve one or both sides of the body, multiple limbs, or a single limb. The paralysis may affect different parts of the body at different times and may be brief or last for several days. A characteristic feature of AHC is that symptoms disappear during sleep and return upon waking. Many affected children display some degree of developmental delay, abnormal eye (oculomotor) movements, uncontrolled limb movements (including ataxia, dystonia, and choreoathetosis) and seizures.  

The majority of cases of AHC are caused by a new change (called a mutation or pathogenic variant) in the ATP1A3 gene that is not inherited. Thus, most patients with AHC do not have a family history of the disorder. A small number of cases of AHC are caused by changes in the ATP1A2 gene. When this condition does run in families, it follows an autosomal dominant pattern of inheritance.Treatment is limited to therapies that can help reduce the severity and duration of symptoms. 

What are the alternative names for Alternating Hemiplegia of Childhood?

  • Alternating hemiplegia syndrome
  • AHC
  • Alternating hemiplegia

Top Global Doctors For Alternating Hemiplegia of Childhood

SJ
Elite
Sung H. Jang
Daegu, KR
RB
Elite
Roslyn N. Boyd
Bundaberg, QLD, AU
EP
Distinguished
Eleni Panagiotakaki
Lyon, FR

Latest Advances On Alternating Hemiplegia of Childhood

  • Condition: Childhood Hemiparesis
  • Journal: Revista de neurologia
  • Treatment Used: Constraint-Induced Movement Therapy
  • Number of Patients: 203
  • Published —
The study researched the outcomes of constraint-induced movement therapy for treating childhood hemiparesis.
  • Condition: Spastic Hemiplegia
  • Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • Treatment Used: Jin 's Three-Needle with MyoTrac Biostimulation Therapy
  • Number of Patients: 120
  • Published —
The study researched the outcomes of Jin 's three-needle combined with MyoTrac biostimulation therapy for treating children with spastic hemiplegia.

Clinical Trials For Alternating Hemiplegia of Childhood

Clinical Trial
  • Status: Not yet recruiting
  • Phase: N/A
  • Intervention Type: Other
  • Participants: 36
  • Start Date: December 1, 2021
Comparison of Three Dimensional Virtual Reality Therapy and Motor Imaging in Functional Recovery of Upper Extremity After Stroke
Clinical Trial
  • Status: Not yet recruiting
  • Phase: N/A
  • Intervention Type: Diagnostic Test
  • Participants: 60
  • Start Date: September 1, 2021
Evaluation of Ultrasonography as a Screening Tool for Dysphagia in Patients With Stroke: Correlation With Videofluoroscopic Study