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Condition

Alternating Hemiplegia of Childhood

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Alternating Hemiplegia of Childhood?

Alternating hemiplegia of childhood (AHC) is a neurological disorder that usually affects children before 18 months of age. Classic AHC causes recurrent episodes of paralysis (hemiplegia) that involve one or both sides of the body, multiple limbs, or a single limb. The paralysis may affect different parts of the body at different times and may be brief or last for several days. A characteristic feature of AHC is that symptoms disappear during sleep and return upon waking. Many affected children display some degree of developmental delay, abnormal eye (oculomotor) movements, uncontrolled limb movements (including ataxia, dystonia, and choreoathetosis) and seizures.  

The majority of cases of AHC are caused by a new change (called a mutation or pathogenic variant) in the ATP1A3 gene that is not inherited. Thus, most patients with AHC do not have a family history of the disorder. A small number of cases of AHC are caused by changes in the ATP1A2 gene. When this condition does run in families, it follows an autosomal dominant pattern of inheritance.Treatment is limited to therapies that can help reduce the severity and duration of symptoms. 

What are the alternative names for Alternating Hemiplegia of Childhood?

  • Alternating hemiplegia syndrome
  • AHC
  • Alternating hemiplegia

Top Global Doctors

SF
Elite
Simona Fiori
Pisa, 52, IT
LS
Elite
Leanne Sakzewski
Brisbane, QLD, AU
MS
Elite
Masayuki Sasaki
Higashi, 40, JP
RB
Elite
Roslyn N. Boyd
Brisbane, QLD, AU
AG
Elite
Andrea Guzzetta
Pisa, 52, IT

Latest Research

Latest Advance
Study
  • Condition: Mucosal Melanoma of Eustachian Tube
  • Journal: The Journal of international medical research
  • Treatment Used: Local Radical Resection Combined with Radiotherapy and Systemic Chemotherapy
  • Number of Patients: 1
  • Published —
This case report describes a 62-year-old woman with internal carotid artery (ICA) rupture after resection of locally advanced mucosal malignant melanoma of the eustachian tube.
Latest Advance
Study
  • Condition: Hemiplegia after Ischemic Stroke
  • Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion
  • Treatment Used: Dynamic Scalp Acupuncture combined with Task-Oriented Mirror Therapy
  • Number of Patients: 78
  • Published —
This study tested the safety and efficacy of using dynamic scalp acupuncture combined with task-oriented mirror therapy to treat patients with hemiplegia after ischemic stroke.

Clinical Trials

Clinical Trial
Other
  • Status: Not yet recruiting
  • Participants: 1600
  • Start Date: January 1, 2021
Prediction of Patient-specific Outcomes After Interventional Neuroradiology Procedures
Clinical Trial
Other
  • Status: Not yet recruiting
  • Study Type: Other
  • Participants: 80
  • Start Date: January 2021
Immersive Virtual Reality for Visuo-motor Integration Skill Assessment in Children With Hemiplegia