Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness

Status: Recruiting
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Maximum Age: 80
Healthy Volunteers: f
View:

• Age 60-80 years

• Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI)

• mini-mental-scale (MMSE) score between 24-30

• Positive plasma pTau217 biomarker

• Stable dose of iAChE therapy (if applicable)

• Ability to participate in a 9-month intervention

Time Frame
Start Date: 2024-11-01
Estimated Completion Date: 2026-12
Participants
Target number of participants: 48
Treatments
Experimental: Mindfulness Yoga and Time-Restricted Eating Intervention
Participants in this arm will take part in a 9-month intervention consisting of yoga-based mindfulness sessions combined with time-restricted eating (16:8 protocol). The yoga program includes physical postures (asanas), breathing techniques, and meditation, aimed at improving physical fitness, stress regulation, and cognitive function. The dietary component promotes a flexitarian diet within an 8-hour daily eating window. Sessions are conducted twice weekly for 90 minutes under certified instructors.
Active_comparator: Cognitive Training and Stretching Intervention
Participants in this arm will engage in a 9-month intervention including cognitive training exercises and guided stretching. The cognitive program targets multiple domains: verbal and non-verbal memory, executive functions, attention, language, and social cognition. Sessions are delivered twice weekly for 90 minutes by trained therapists. This intervention serves as an active comparator for assessing the effects of yoga and dietary modification on cognitive and biological outcomes.
Related Therapeutic Areas
Sponsors
Collaborators: Slovak Academy of Sciences
Leads: St. Anne's University Hospital Brno, Czech Republic

This content was sourced from clinicaltrials.gov