MediFind
Condition

Amenorrhea

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Amenorrhea?

Absence of a woman's monthly menstrual period is called amenorrhea.

Primary amenorrhea is when a girl has not yet started her monthly periods, and she:

  • Has gone through other normal changes that occur during puberty
  • Is older than 15

What are the alternative names for Amenorrhea?

Primary amenorrhea; No periods - primary; Absent periods - primary; Absent menses - primary; Absence of periods - primary

What are the causes for Amenorrhea?

Most girls begin their periods between ages 9 and 18. The average is around 12 years old. If no periods have occurred when a girl is older than 15, further testing may be needed. The need is more urgent if she has gone through other normal changes that occur during puberty.

Being born with incompletely formed genital or pelvic organs can lead to a lack of menstrual periods. Some of these defects include:

  • Blockages or narrowing of the cervix
  • Hymen that has no opening
  • Missing uterus or vagina
  • Vaginal septum (a wall that divides the vagina into 2 sections)

Hormones play a big role in a woman's menstrual cycle. Hormone problems can occur when:

  • Changes occur to the parts of the brain where hormones that help manage the menstrual cycle are produced.
  • The ovaries are not working correctly.

Either of these problems may be due to:

  • Anorexia (loss of appetite)
  • Chronic or long-term illnesses, such as cystic fibrosis or heart disease
  • Genetic defects or disorders
  • Infections that occur in the womb or after birth
  • Other birth defects
  • Poor nutrition
  • Tumors

In many cases, the cause of primary amenorrhea is not known.

What are the symptoms for Amenorrhea?

A female with amenorrhea will have no menstrual flow. She may have other signs of puberty.

What are the current treatments for Amenorrhea?

Treatment depends on the cause of the missing period. Lack of periods that is caused by birth defects may require hormone medicines, surgery, or both.

If the amenorrhea is caused by a tumor in the brain:

  • Medicines may shrink certain types of tumors.
  • Surgery to remove the tumor may also be needed.
  • Radiation therapy is usually only done when other treatments have not worked.

If the problem is caused by a systemic disease, treatment of the disease may allow menstruation to begin.

If the cause is the bulimia, anorexia or too much exercise, periods will often begin when the weight returns to normal or the exercise level is decreased.

If the amenorrhea cannot be corrected, hormone medicines can sometimes be used. Medicines can help the woman feel more like her friends and female family members. They can also protect the bones from becoming too thin (osteoporosis).

What is the outlook (prognosis) for Amenorrhea?

The outlook depends on the cause of the amenorrhea and whether it can be corrected with treatment or lifestyle changes.

Periods are not likely to start on their own if the amenorrhea was caused by one of the following conditions:

  • Birth defects of the female organs
  • Craniopharyngioma (a tumor near the pituitary gland at the base of the brain)
  • Cystic fibrosis
  • Genetic disorders

You may have emotional distress because you feel different from friends or family. Or, you may worry that you might not be able to have children.

When should I contact a medical professional for Amenorrhea?

Call your provider if your daughter is older than 15 and has not yet begun menstruating, or if she is 14 and shows no other signs of puberty.

Primary
Normal
Absence

REFERENCES

Bulun SE. Physiology and pathology of the female reproductive axis. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 17.

Lobo RA. Primary and secondary amenorrhea and precocious puberty: etiology, diagnostic evaluation, management. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 38.

Magowan BA, Owen P, Thomson A. The normal menstrual cycle and amenorrhoea. In: Magowan BA, Owen P, Thomson A, eds. Clinical Obstetrics and Gynaecology. 4th ed. Elsevier; 2019:chap 4.

Latest Research

Latest Advance
Study
  • Condition: Prevention of Primary Postpartum Hemorrhage
  • Journal: The Pan African medical journal
  • Treatment Used: 400?g Sublingual Misoprostol
  • Number of Patients: 211
  • Published —
This study determined whether a 400?g dose of misoprostol decreases the incidence of postpartum hemorrhage (PPH) in women who did not show signs of hemorrhage.
Latest Advance
Study
  • Condition: Lupus Nephritis
  • Journal: Medicine
  • Treatment Used: Mycophenolate Mofetil
  • Number of Patients: 927
  • Published —
This study tested the safety and efficacy of using mycophenolate mofetil to treat patients with lupus nephritis.

Clinical Trials

Clinical Trial
Drug
  • Status: Not yet recruiting
  • Study Type: Drug
  • Participants: 26
  • Start Date: January 1, 2021
Gonadotropin and Steroid Hormone Secretion in Transgender Males
Clinical Trial
Other
  • Status: Not yet recruiting
  • Study Type: Other
  • Participants: 172
  • Start Date: January 2021
Efficacy of Acupunture on Menstrual Frequency in Women With Polycystic Ovary Syndrome: Protocol for a Randomized, Controlled Trial