Impact of Metabolic Status and Circadian Rhythms on Post-chemotherapy Ovarian Recovery in Women Treated for Breast Cancer

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Chemotherapy for cancer, due to its gonadotoxicity, can lead to impaired female fertility, resulting in the occurrence of transient or prolonged chemo-induced amenorrhea (CIA). According to recent data from the National Cancer Institute, 11.9% of women under the age of 40 diagnosed with cancer have been offered a fertility evaluation within five years of diagnosis. Predicting the risk and especially the duration of the CIA remains difficult. Known factors predicting a rapid return of menstruation are a young age at diagnosis, a low gonadotoxic treatment (absence of alkylating agents) and a high pre-chemotherapy blood level of AMH reflecting a large pool of growing follicles. A body mass index (BMI) ≥ 25 kg / m² could also be a positive predictor, but this remains debated. The objective of this project is to assess the impact of metabolism and energy reserves, physical activity and the chronotype on the recovery of ovarian function in patients with breast cancer who have developed CIA

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 25
Maximum Age: 35
Healthy Volunteers: f
View:

• Women with a chemotherapy-induced (CIA) amenorrhea who asked for post-cancer fertility follow-up at the University Hospital of Lille, France.

• Women between 25 to 35 years age at inclusion

• Chemotherapy protocol: FEC 100 (3 cycles) + docetaxel (3 cycles

Locations
Other Locations
France
Hop Jeanne de Flandre Chu Lille
RECRUITING
Lille
Contact Information
Primary
Pascal PIGNY, MD,PhD
pascal.pigny@chru-lille.fr
0320445962
Time Frame
Start Date: 2022-02-24
Estimated Completion Date: 2026-06
Participants
Target number of participants: 50
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Lille

This content was sourced from clinicaltrials.gov