Development of a Protocol for Non-Invasive Prenatal Analysis of Cell-Free Circulating Fetal DNA (ccfDNA) Using Massively Parallel Sequencing (MPS)

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In criminal cases involving sexual assault, victims may later discover they are pregnant, creating profound uncertainty about the paternity of the fetus. These distressing situations compound the trauma already experienced by the victims. To address this, the Medico-Legal Hematology Laboratory (LHML) in Bordeaux aims to validate a method based on Massively Parallel Sequencing (MPS) and a specific isolation protocol for analyzing cell-free circulating fetal DNA (ccfDNA) in maternal blood samples. This identification process will confirm or exclude paternal genetic relationships between the fetus and potential fathers between 6 and 22 weeks of amenorrhea. These analyses will only be conducted under judicial requisition, in accordance with the French Code of Criminal Procedure

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Age 18 or older.

• For woman: pregnancy between 6 and 22 weeks

• For both mother and father: non-opposition to participate and genetic signed informed consent

Locations
Other Locations
France
CHU Bordeaux
RECRUITING
Bordeaux
Contact Information
Primary
Loic Sentilhes, MD, PhD
loic.sentilhes@chu-bordeaux.fr
+33 556 79 55 79
Time Frame
Start Date: 2025-09-15
Estimated Completion Date: 2026-09
Participants
Target number of participants: 60
Treatments
Experimental: Genetic profile
Filiation analysis between the fetus and his father
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Bordeaux

This content was sourced from clinicaltrials.gov