The Research of Integrated Traditional Chinese and Western Medicine on Hypothalamic Amenorrhea
This study aims to validate the efficacy and safety of the two-step cycle-regulating approach integrating Chinese and Western medicine: rapid restoration of menstruation with Western medicine, and nourish the kidney and soothe the liver, nourishing the essence, and reinforcing the vital essence and strengthening the primordial qi with Chinese medicine through a nationwide randomized controlled clinical trial involving 210 cases. Guided by traditional Chinese medicine theory, the study will explore the mechanism of integrated Chinese and Western medicine in the treatment of functional hypothalamic amenorrhea through gut microbiota and metabolomics research.
⁃ Diagnostic criteria for functional hypothalamic amenorrhea
• primary or secondary amenorrhea
• Normal or low FSH levels, LH \< 5 IU/L, E2 \< 50 pg/mL
• Exclusion of amenorrhea caused by: -Organic lesions of the hypothalamus or pituitary gland , Ovarian amenorrhea , Uterine or lower genital tract developmental abnormalities ,Drug-induced amenorrhea ,Other causes of amenorrhea