Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease)

Symptoms, Doctors, Treatments, Advances & More

Amyotrophic lateral sclerosis, or ALS, is a disease of the nerve cells in the brain, brain stem and spinal cord that control voluntary muscle movement.

ALS is also known as Lou Gehrig disease.

Lou Gehrig disease; ALS; Upper and lower motor neuron disease; Motor neuron disease

About 1 in 10 cases of ALS is due to a genetic variant. The cause is unknown in most other cases.

In ALS, motor nerve cells (neurons) waste away or die, and can no longer send messages to muscles. This eventually leads to muscle weakening, twitching, and an inability to move the arms, legs, and body. The condition continues to get worse. When the muscles in the chest area stop working, it becomes hard or impossible to breathe.

ALS affects approximately 7 out of every 100,000 people worldwide.

Having a family member who has a hereditary form of the disease is a risk factor for ALS. ALS is more common with increased age and in men. Exposure to toxins, strenuous activity, and traumatic brain injury are also risk factors. Other risks include military service. The reasons for this are unclear, but it may have to do with environmental exposure to toxins.

Symptoms usually do not develop until after age 50, but they can start in younger people. People with ALS have a loss of muscle strength and coordination that eventually gets worse and makes it impossible for them to do routine tasks such as going up steps, getting out of a chair, or swallowing.

Weakness can first affect the arms or legs, or the ability to breathe or swallow. As the disease gets worse, more muscle groups develop problems.

ALS does not affect the senses (sight, smell, taste, hearing, touch). Most people are able to think normally, although a small number develop dementia and behavioral problems.

Muscle weakness starts in one body part, such as the arm or hand, and slowly gets worse until it leads to the following:

• Difficulty lifting, climbing stairs, and walking
• Difficulty breathing
• Difficulty swallowing -- choking easily, drooling, or gagging
• Head drop due to weakness of the neck muscles
• Speech problems, such as a slow or abnormal speech pattern (slurring of words)
• Voice changes, hoarseness

Other findings include:

• Depression
• Changing expressions of emotions (emotional lability)
• Muscle cramps
• Muscle stiffness, called spasticity
• Muscle contractions, called fasciculations
• Weight loss

There is no known cure for ALS. Three medicines are available that help slow the progression of symptoms and may help people live slightly longer:

• Riluzole (Rilutek)
• Edaravone (Radicava)
• Tofersen (Qalsody) – only used in one specific form of familial ALS

Treatments to control other symptoms include:

• Baclofen or diazepam for spasticity that interferes with daily activities
• Trihexyphenidyl or amitriptyline for people with problems swallowing their own saliva
• Botulinum toxin for spasticity or too much saliva
• Dextromethorphan/quinidine (Neudexta) to treat pseudobulbar affect

Trials of gene therapy are now underway for some specific hereditary causes.

Physical therapy, rehabilitation, use of braces or a wheelchair, or other measures may be needed to help with muscle function and general health. Ongoing oversight by a physical therapist is helpful, given continuously changing symptoms.

People with ALS tend to lose weight. People with ALS lose muscle mass. The illness itself increases the need for food and calories. At the same time, problems with choking and swallowing make it hard to eat enough. To help with feeding, a tube may be placed into the stomach. A dietitian who specializes in ALS can give advice on healthy eating.

Breathing devices include machines that are considered non-invasive (such as CPAP or BiPAP). Others require a tube in the trachea (invasive ventilation).

Medicine for depression may be needed if a person with ALS is diagnosed with depression. They also should discuss their wishes regarding artificial ventilation with their families and providers.

Emotional support is vital in coping with the disorder, because mental functioning is not affected. Groups such as the ALS Association may be available to help people who are coping with the disorder.

Support for people who are caring for someone with ALS is also available, and may be very helpful.

Over time, people with ALS lose the ability to function and care for themselves. Death often occurs within 2 to 4 years of diagnosis. About 1 in 4 people survive for more than 5 years after diagnosis. Some people live much longer, but they typically need help breathing from a ventilator or other device.

Complications of ALS include:

• Breathing in food or fluid (aspiration)
• Loss of ability to care for self
• Lung failure
• Pneumonia
• Pressure sores
• Weight loss

Contact your provider if:

• You have symptoms of ALS, particularly if you have a family history of the disorder
• You or someone else has been diagnosed with ALS and symptoms get worse or new symptoms develop

Increased difficulty swallowing, difficulty breathing, and episodes of apnea are symptoms that require immediate attention.

You may want to see a genetic counselor if you have a family history of ALS.

Published Date: May 04, 2026
Published By: Joseph V. Campellone, MD, Professor of Neurology, Cooper-Inspira Neuroscience, Cooper Medical School of Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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Shaw PJ, Cudkowicz ME. Amyotrophic lateral sclerosis and other motor neuron diseases. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 387.