Dissezione Fenotipica Guidata da Biomarcatori Della Sclerosi Laterale Amiotrofica/Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
Status: Recruiting
Location: See all (3) locations...
Study Type: Observational
SUMMARY
The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are: * Which set of biomarkers explain genotypic-phenotypic correlations in ALS? * Which set of biomarkers can be used to subdivide the ALS population in homogeneous subgroups? Participants will undergo: * neurological evaluation * neurophysiological evaluation * neuropsychological evaluation * whole exome sequencing * biomarker measurement in CSF and plasma
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• diagnosis of ALS or other motor neuron disease
• residence near the study centers
Locations
Other Locations
Italy
Ospedale San Luca
RECRUITING
Milan
Ospedale San Raffaele
RECRUITING
Milan
AOU Città della Salute e della Scienza
RECRUITING
Torino
Contact Information
Primary
Nicola Ticozzi, MD, PhD
n.ticozzi@auxologico.it
+390261911
Time Frame
Start Date: 2023-04-11
Estimated Completion Date: 2026-04-10
Participants
Target number of participants: 200
Related Therapeutic Areas
Sponsors
Leads: Istituto Auxologico Italiano
Collaborators: Ospedale San Raffaele, A.O.U. Città della Salute e della Scienza