Primary Lateral Sclerosis Overview

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Learn About Primary Lateral Sclerosis

What is the definition of Primary Lateral Sclerosis?
Primary lateral sclerosis (PLS) is a rare neuromuscular disease that affects the nerve cells that control the voluntary muscles. Problems in the legs (such as weakness, stiffness, spasticity, and balance problems) are often observed first, but hand clumsiness and changes in speech can be early symptoms, as well. The underlying cause of adult PLS is currently unknown. In most cases, it occurs sporadically in people with no family history of the condition. A subtype of PLS, called juvenile PLS, is caused by changes in the ALS2 gene and is inherited in an autosomal recessive manner.
What are the alternative names for Primary Lateral Sclerosis?
  • Primary lateral sclerosis
  • Adult-onset PLS
  • Adult-onset primary lateral sclerosis
Who are the top Primary Lateral Sclerosis Local Doctors?
Thomas A. Meyer
Thomas A. Meyer
Thomas A. Meyer
St. Josef Hospital, 
Bochum, NW, DE 

Thomas Meyer practices in Bochum, Germany. Meyer and is rated as an Elite expert by MediFind in the treatment of Primary Lateral Sclerosis. His top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Primary Lateral Sclerosis, Squamous Cell Skin Carcinoma, Gastrostomy, and Bone Graft.

Richard J. Barohn
Dr. Richard J. Barohn
Neurology
Dr. Richard J. Barohn
Neurology

The Curators Of The University Of Missouri

1020 Hitt St, Neurology Clinic Univ Of Mo, 
Columbia, MO 
573-882-3133
Languages Spoken:
English
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Accepting New Patients

Richard Barohn is a Neurologist in Columbia, Missouri. Dr. Barohn and is rated as an Elite provider by MediFind in the treatment of Primary Lateral Sclerosis. His top areas of expertise are Inclusion Body Myositis, Myasthenia Gravis, Myositis, Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), and Thymectomy. Dr. Barohn is currently accepting new patients.

 
 
 
 
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Markus F. Weber
Markus F. Weber
Markus F. Weber
Franz Josef Strauß Allee 11, 
Regensburg, BY, DE 

Markus Weber practices in Regensburg, Germany. Weber and is rated as an Elite expert by MediFind in the treatment of Primary Lateral Sclerosis. His top areas of expertise are Primary Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Cramp-Fasciculation Syndrome, Hip Replacement, and Knee Replacement.

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What are the latest Primary Lateral Sclerosis Clinical Trials?
First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ALN-SOD in Participants With Amyotrophic Lateral Sclerosis and SOD1 Mutations
First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ALN-SOD in Participants With Amyotrophic Lateral Sclerosis and SOD1 Mutations
Enrollment Status: Recruiting
Publish Date: February 26, 2025
Intervention Type: Other, Drug
Study Phase: Phase 1

Summary: This study is researching an experimental drug called ALN-SOD (called study drug). This study is focused on people with amyotrophic lateral sclerosis (ALS) caused by a change in a gene called the superoxide dismutase-1 (SOD1) gene. This type of ALS is known as SOD1-ALS. This is the first time that ALN-SOD will be given to people. The aim of the study is to see how safe and tolerable the study drug...

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The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Enrollment Status: Recruiting
Publish Date: February 26, 2025

Summary: Pre-fALS is a prospective natural history and biomarker study of people not yet affected with ALS, but who are at genetic risk for developing ALS. The investigators aim to recruit unaffected (healthy) people from familial ALS (fALS) pedigrees in which a known genetic mutation associated with ALS has been identified; for this study, a fALS pedigree is one with two biologically related individuals w...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center