Primary Lateral Sclerosis
Symptoms, Doctors, Treatments, Advances & More

Primary Lateral Sclerosis Overview

Save information for later
Sign Up

Learn About Primary Lateral Sclerosis

What is the definition of Primary Lateral Sclerosis?
Primary lateral sclerosis (PLS) is a rare neuromuscular disease that affects the nerve cells that control the voluntary muscles. Problems in the legs (such as weakness, stiffness, spasticity, and balance problems) are often observed first, but hand clumsiness and changes in speech can be early symptoms, as well. The underlying cause of adult PLS is currently unknown. In most cases, it occurs sporadically in people with no family history of the condition. A subtype of PLS, called juvenile PLS, is caused by changes in the ALS2 gene and is inherited in an autosomal recessive manner.
What are the alternative names for Primary Lateral Sclerosis?
  • Primary lateral sclerosis
  • Adult-onset PLS
  • Adult-onset primary lateral sclerosis
Who are the top Primary Lateral Sclerosis Local Doctors?
Elite in Primary Lateral Sclerosis
Elite in Primary Lateral Sclerosis
Referral may be required

VCU Health - Ambulatory Care Center

417 N. 11th Street, 
Richmond, VA 
804-828-9350
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Kelly Gwathmey is a Neurologist practicing medicine in Richmond, Virginia. Dr. Gwathmey is rated as an Elite provider by MediFind in the treatment of Primary Lateral Sclerosis. She is also highly rated in 52 other conditions, according to our data. Her clinical expertise encompasses Myasthenia Gravis, Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Chronic Inflammatory Demyelinating Polyneuropathy, Gastrostomy, and Tissue Biopsy. Dr. Gwathmey is currently accepting new patients.

Elite in Primary Lateral Sclerosis
Elite in Primary Lateral Sclerosis
Referral may be required

Office

7595 SW 33rd St Ste 405, 
Davie, FL 
954-262-4100
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Eduardo Locatelli is a Neurologist practicing medicine in Davie, Florida. Dr. Locatelli is rated as an Elite provider by MediFind in the treatment of Primary Lateral Sclerosis. He is also highly rated in 14 other conditions, according to our data. His clinical expertise encompasses Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Primary Lateral Sclerosis, Spinal and Bulbar Muscular Atrophy, and Spinal Muscular Atrophy Type 3.

 
 
 
 
Learn about our expert tiers
Learn More
Elite in Primary Lateral Sclerosis
Dr. Michael G. Benatar
Neuromusculoskeletal Medicine | Neurology
Elite in Primary Lateral Sclerosis
Dr. Michael G. Benatar
Neuromusculoskeletal Medicine | Neurology
Referral may be required
1150 Northwest 14th Street, 
Miami, FL 
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Michael Benatar is a Neuromusculoskeletal Medicine specialist and a Neurologist practicing medicine in Miami, Florida. Dr. Benatar is rated as an Elite provider by MediFind in the treatment of Primary Lateral Sclerosis. He is also highly rated in 10 other conditions, according to our data. His clinical expertise encompasses Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Primary Lateral Sclerosis, Myasthenia Gravis, Frontotemporal Dementia, and Thymectomy. Dr. Benatar is currently accepting new patients.

View All Doctors
What are the latest Primary Lateral Sclerosis Clinical Trials?
Clinical and Molecular Manifestations of Inherited Neurological Disorders
Clinical and Molecular Manifestations of Inherited Neurological Disorders
Enrollment Status: Recruiting
Publish Date: September 08, 2026

Summary: This study is designed to learn more about the natural history of inherited neurological disorders and the role of heredity in their development. It will examine the genetics, symptoms, disease progression, treatment, and psychological and behavioral impact of diseases in the following categories: hereditary peripheral neuropathies; hereditary myopathies; muscular dystrophies; hereditary motor neu...

Match to trials
Find the right clinical trials for you in under a minute
Get started
A Registry of Cases of Spinal Muscular Atrophy Diagnosed in the Prenatal Period That Received Disease-Modifying Therapy
A Registry of Cases of Spinal Muscular Atrophy Diagnosed in the Prenatal Period That Received Disease-Modifying Therapy
Enrollment Status: Recruiting
Publish Date: September 08, 2026

Summary: Because no long-term record of prenatal Spinal Muscular Atrophy (SMA) treatment exists, this study will address an important gap in the understanding of the safety and benefit of treatment while in the womb. The registry will help guide best practices for monitoring pregnant women and their fetus with SMA, if treated with a medication while in the womb, and to follow the baby after birth for signs...

View All Clinical Trials
Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center