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Learn About Primary Lateral Sclerosis

What is the definition of Primary Lateral Sclerosis?
Primary lateral sclerosis (PLS) is a rare neuromuscular disease that affects the nerve cells that control the voluntary muscles. Problems in the legs (such as weakness, stiffness, spasticity, and balance problems) are often observed first, but hand clumsiness and changes in speech can be early symptoms, as well. The underlying cause of adult PLS is currently unknown. In most cases, it occurs sporadically in people with no family history of the condition. A subtype of PLS, called juvenile PLS, is caused by changes in the ALS2 gene and is inherited in an autosomal recessive manner.
What are the alternative names for Primary Lateral Sclerosis?
  • Primary lateral sclerosis
  • Adult-onset PLS
  • Adult-onset primary lateral sclerosis
Who are the top Primary Lateral Sclerosis Local Doctors?
Jonathan D. Glass
Elite in Primary Lateral Sclerosis
Neuromusculoskeletal Medicine
Elite in Primary Lateral Sclerosis
Neuromusculoskeletal Medicine

Emory Brain Health Center

12 Executive Park Drive Northeast, 
Atlanta, GA 
Experience:
40+ years
Languages Spoken:
English
Offers Telehealth

Jonathan Glass is a Neuromusculoskeletal Medicine provider in Atlanta, Georgia. Dr. Glass has been practicing medicine for over 40 years and is rated as an Elite provider by MediFind in the treatment of Primary Lateral Sclerosis. His top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Primary Lateral Sclerosis, Spinal Muscular Atrophy (SMA), Lithotripsy, and Gastrostomy.

Leo F. Mccluskey
Elite in Primary Lateral Sclerosis
Neurology | Neuromusculoskeletal Medicine
Elite in Primary Lateral Sclerosis
Neurology | Neuromusculoskeletal Medicine

Atrium Health Neurology Specialty Care, A Facility Of Carolinas Medical Center

1010 Edgehill Road N., 
Charlotte, NC 
Languages Spoken:
English
Accepting New Patients
Offers Telehealth

Leo Mccluskey is a Neurologist and a Neuromusculoskeletal Medicine provider in Charlotte, North Carolina. Dr. Mccluskey is rated as an Elite provider by MediFind in the treatment of Primary Lateral Sclerosis. His top areas of expertise are Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Primary Lateral Sclerosis, Spinal Muscular Atrophy (SMA), and Spinal and Bulbar Muscular Atrophy. Dr. Mccluskey is currently accepting new patients.

 
 
 
 
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Markus F. Weber
Elite in Primary Lateral Sclerosis
Elite in Primary Lateral Sclerosis
Franz Josef Strauß Allee 11, 
Regensburg, BY, DE 

Markus Weber practices in Regensburg, Germany. Mr. Weber is rated as an Elite expert by MediFind in the treatment of Primary Lateral Sclerosis. His top areas of expertise are Primary Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease), Riboflavin Transporter Deficiency Neuronopathy, Hip Replacement, and Knee Replacement.

What are the latest Primary Lateral Sclerosis Clinical Trials?
Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)

Background: Amyotrophic lateral sclerosis (ALS) is a disorder that damages nerve cells in the brain and spinal cord. It can cause muscle weakness, paralysis, and loss of movement. The symptoms grow worse over time. Half of all people with ALS live only 3 to 5 years after diagnosis. Current drug treatments can slow the progress of the disease, but they cannot stop or reverse it.

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Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Background: Neurodegenerative disorders can lead to problems in movement or memory. Some can cause abnormal proteins to build up in brain cells. Researchers want to understand whether these diseases have related causes or risk factors.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center