Learn About Andersen-Tawil Syndrome

What is the definition of Andersen-Tawil Syndrome?

Andersen-Tawil syndrome is a disorder that causes episodes of muscle weakness (periodic paralysis), changes in heart rhythm (arrhythmia), and developmental abnormalities. Periodic paralysis begins early in life, and episodes last from hours to days. These episodes may occur after exercise or long periods of rest, but they often have no obvious trigger. Muscle strength usually returns to normal between episodes. However, mild muscle weakness may eventually become permanent.

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What are the causes of Andersen-Tawil Syndrome?

Mutations in the KCNJ2 gene cause about 60 percent of all cases of Andersen-Tawil syndrome. When the disorder is caused by mutations in this gene, it is classified as type 1 (ATS1).

How prevalent is Andersen-Tawil Syndrome?

Andersen-Tawil syndrome is a rare genetic disorder. Its exact prevalence is unknown, although it is estimated to affect 1 in 1 million people worldwide. About 200 affected individuals have been described in the medical literature. Researchers believe that Andersen-Tawil syndrome accounts for less than 10 percent of all cases of periodic paralysis.

Is Andersen-Tawil Syndrome an inherited disorder?

This condition is inherited in an autosomal dominant pattern, which means one copy of an altered gene in each cell is sufficient to cause the disorder. When the condition results from a mutation in the KCNJ2 gene, an affected individual may inherit the mutation from one affected parent. In other cases, the condition results from a new (de novo) mutation in the KCNJ2 gene. These cases occur in people with no history of the disorder in their family.

Who are the top Andersen-Tawil Syndrome Local Doctors?
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Instituto Nacional De Cardiología Ignacio Chávez

Ignacio Chavez, DIF, MX 

Manlio Marquez is in Ignacio Chavez, Mexico. Marquez is rated as an Elite expert by MediFind in the treatment of Andersen-Tawil Syndrome. He is also highly rated in 15 other conditions, according to our data. His top areas of expertise are Andersen-Tawil Syndrome, Long QT Syndrome, Familial Neurocardiogenic Syncope, and Fainting.

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Highly rated in
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Universidad De La Frontera

Department Of Genetics And Molecular Biology 
Paso Nacional, OAX, MX 

Armando Serra-Totomoch is in Paso Nacional, Mexico. Serra-Totomoch is rated as an Elite expert by MediFind in the treatment of Andersen-Tawil Syndrome. He is also highly rated in 2 other conditions, according to our data. His top areas of expertise are Andersen-Tawil Syndrome, Long QT Syndrome, Hiccups, and Hydatidosis.

 
 
 
 
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Shiga University Of Medical Science

Department Of Cardiovascular Medicine 
JP 

Minoru Horie is in Japan. Horie is rated as an Elite expert by MediFind in the treatment of Andersen-Tawil Syndrome. He is also highly rated in 38 other conditions, according to our data. His top areas of expertise are Familial Ventricular Tachycardia, Long QT Syndrome, Ventricular Tachycardia, and Arrhythmias.

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Who are the sources who wrote this article ?

Published Date:updated Last, April

Published By: National Institutes of Health

What are the Latest Advances for Andersen-Tawil Syndrome?

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