Intravenous Iron to Treat Postoperative Anemia in Older Cardiac Surgery Patients: a Randomized Controlled Trial'
Postoperative anemia is common in cardiac surgery with cardiopulmonary bypass. Iron deficiency delays the recovery from postoperative anemia and may negatively affect the postoperative trajectory of cardiac surgery patients. The objective of the study is to determine the effect of treatment of postoperative iron deficiency anemia with intravenous iron on disability 90 days after surgery. This will be evaluated in a randomized placebo-controlled double blind two-center trial in which 310 elective cardiac surgery patients will be included.
• Mentally competent with age ≥ 70 years
• Elective AVR or CABG surgery
• Expected uncomplicated postoperative trajectory, defined as:
• No inotropic agents or ventilation at time of final inclusion (POD 1)
• Expected discharge to general ward at POD 1
• Moderate postoperative IDA, defined as:
• Hb between 85 and 110 g/L and
• Ferritin \<100 µg/L or
• Iron saturation (TSAT) \< 20%