Learn About Angioimmunoblastic T-cell Lymphoma

What is the definition of Angioimmunoblastic T-cell Lymphoma?
Angioimmunoblastic T-cell lymphoma (AITL) is a rare, aggressive type of non-Hodgkin lymphoma or peripheral T-cell lymphoma (PTCL), which is a cancer that affects the lymphatic system. The lymphatic system and white blood cells are part of the immune system that helps protect the body against infection and disease. Lymphomas involve cancer of the white blood cells (lymphocytes) and are classified by the type of white blood cells involved: either B-lymphocytes (B-cells) or T-lymphocytes (T-cells). In angioimmunoblastic T-cell lymphoma, a T-cell transforms into a malignant (cancerous) cell that leads to a dysfunction of the immune system. Angioimmunoblastic T-cell lymphoma mainly affects the elderly.
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What are the symptoms of Angioimmunoblastic T-cell Lymphoma?
Symptoms of angioimmunoblastic T-cell lymphoma may include an enlargement of the lymph nodes and other lymphatic organs, such as the spleen and bone marrow; fatigue; pale skin; dark urine; malaise; persistent high fever; night sweats; unintended weight loss; edema (swelling); pleural effusion (fluid around lungs); shortness of breath; rapid heartbeat; abdominal fluid (ascites); rash; itching; liver enlargement; bruising; vasculitis (inflammation of blood vessels); neurological abnormalities, such as confusion, apathy, tinnitus (ringing in the ears), nerve inflammation (polyneuritis), eye swelling, and hearing or visual impairment; gastrointestinal abnormalities, such as ulcers, diarrhea, gastrointestinal bleeding, and intestinal polyps, inflammation of the bile ducts; and autoimmune disorders, such as autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (low platelets; ITP).
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What are the current treatments for Angioimmunoblastic T-cell Lymphoma?
Some patients with angioimmunoblastic T-cell lymphoma may not initially receive treatment as their doctor may take a wait-and-watch approach until the cancer progresses. Treatment for aggressive angioimmunoblastic T-cell lymphoma includes combined chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) or doxorubicin, vincristine, cyclophosphamide, etoposide, and prednisone (CHOEP); radiation therapy; higher doses of chemotherapy, followed by stem cell transplantation; corticosteroids; and multidrug chemotherapy at the end of treatment. In patients with angioimmunoblastic T-cell lymphoma with a CD30 marker on cancer cells, brentuximab vedotin (Adcetris) may be used in combination with cyclophosphamide, doxorubicin, and prednisone. Since relapse is common for angioimmunoblastic T-cell lymphoma, or for patients who are resistant to treatment, romidepsin (Istodax), belinostat (Beleodaq), or pralatrexate (Folotyn) may be administered. Other treatments following relapse may include high-dose chemotherapy followed by an autologous (patient’s) stem cell transplant or an allogeneic (donor) stem cell transplant. Additional drugs that may be used include enalidomide (Revlimid) alone or in combination with current chemotherapy regimens. Drugs used for other types of lymphoma may also be used for patients with angioimmunoblastic T-cell lymphoma, such as gemcitabine (Gemzar), bortezomib (Velcade), bendamustine (Treanda), or alemtuzumab (Campath).
Who are the top Angioimmunoblastic T-cell Lymphoma Local Doctors?
Elite
Highly rated in
22
conditions

Institute Of Pathology

Lausanne, VD, CH 1011

Laurence De Leval is in Lausanne, Switzerland. De Leval is rated as an Elite expert by MediFind in the treatment of Angioimmunoblastic T-cell Lymphoma. He is also highly rated in 22 other conditions, according to our data. His top areas of expertise are Angioimmunoblastic T-cell Lymphoma, Peripheral T-Cell Lymphoma, T-Cell Lymphoma, and Non-Hodgkin Lymphoma.

Elite
Highly rated in
30
conditions
Oncology

Memorial Hematology Lymphoma Group

1275 York Ave 
New York, NY 10021

Steven Horwitz is an Oncologist in New York, New York. Dr. Horwitz has been practicing medicine for over 29 years and is rated as an Elite doctor by MediFind in the treatment of Angioimmunoblastic T-cell Lymphoma. He is also highly rated in 30 other conditions, according to our data. His top areas of expertise are T-Cell Lymphoma, Peripheral T-Cell Lymphoma, Non-Hodgkin Lymphoma, and Anaplastic Large Cell Lymphoma. He is licensed to treat patients in New York. Dr. Horwitz is currently accepting new patients.

 
 
 
 
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Elite
Highly rated in
9
conditions

Hôpital Henri Mondor

Creteil, FR 94010

Francois Lemonnier is in Creteil, France. Lemonnier is rated as an Elite expert by MediFind in the treatment of Angioimmunoblastic T-cell Lymphoma. He is also highly rated in 9 other conditions, according to our data. His top areas of expertise are Angioimmunoblastic T-cell Lymphoma, Peripheral T-Cell Lymphoma, Lymphofollicular Hyperplasia, and T-Cell Lymphoma.

What are the latest Angioimmunoblastic T-cell Lymphoma Clinical Trials?
Phase I Dose-Escalation Study of CPI-613, in Combination With Bendamustine, in Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Classic Hodgkin Lymphoma
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Efficacy and Safety of Anti-CD30 CAR-T Therapy in Patients With Refractory/Relapsed Lymphocyte Malignancies:a Single-center, Open, Single-arm Clinical Study.
What are the Latest Advances for Angioimmunoblastic T-cell Lymphoma?
Chemotherapy combined with radiotherapy for successful treatment of angioimmunoblastic T-cell lymphoma: a case report.
Effects of stem cell transplantation in patients with peripheral T-cell lymphoma not otherwise specified and angioimmunoblastic T-cell lymphoma.
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Pralatrexate injection for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma.