An abnormal lack of sweat in response to heat may be harmful because sweating allows heat to be released from the body. The medical term for absent sweating is anhidrosis.
Decreased sweating; Anhidrosis
Anhidrosis sometimes goes unrecognized until a substantial amount of heat or exertion fails to cause sweating.
Overall lack of sweating can be life threatening because the body will overheat. If the lack of sweating happens in a small area only, it is usually not as dangerous.
Cause of anhidrosis may include:
If there is a danger of overheating, take the following measures:
Call your health care provider if you have a general lack of sweating or an abnormal lack of sweating when exposed to heat or strenuous exercise.
The provider will perform a physical exam. In emergencies, the health care team will perform rapid cooling measures and give you fluids to stabilize you.
You may be asked about your symptoms and medical history.
You may be asked to wrap yourself in an electric blanket or sit in a sweatbox while the health care team watches your body's reaction. Other tests to cause and measure sweating may also be done.
A skin biopsy may be done. Genetic testing may be done if appropriate.
Treatment depends on the cause of your lack of sweating. You may be given medicine to cause sweating.
Summary: The study will collect clinical information from patients with FD and allow them to give blood to help develop biological markers of the disease to aid diagnosis and treatment. This is a non-invasive, non-interventional, observation study that poses only minimal risk for participants. The study will document the clinical features of patients with FD overtime by storing their routine clinical test ...
Summary: Alpha-1 kinase (ALPK1) has been reported as a potential causative gene for ROSAH Syndrome. Genetic variants including T237M have been found in ROSAH Syndrome patients. Our in-house study has found that T237M mutation leads to hyperactivity of ALPK1, which may be the cause of the inflammatory syndromes found in ROSAH Syndrome patients. We hypothesize that T237M mutation ALPK1 cause ROSAH Syndrome a...
Published Date: June 19, 2021
Published By: Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM. Diseases of the skin appendages. In: James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM, eds. Andrews' Diseases of the Skin. 13th ed. Philadelphia, PA: Elsevier; 2020:chap 33.
Miller JL. Diseases of the eccrine and apocrine sweat glands. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. 4th ed. Philadelphia, PA: Elsevier Saunders; 2018:chap 39.