Anonychia CongenitaSymptoms, Doctors, Treatments, Advances & More
Learn About Anonychia Congenita
Anonychia congenita is a condition that affects the fingernails and toenails. Individuals with this condition are typically missing all of their fingernails and toenails (anonychia). This absence of nails is noticeable from birth (congenital). In some cases, only part of the nail is missing (hyponychia) or not all fingers and toes are affected. All of the other tissues at the tips of the fingers and toes, including structures that usually support the nail and its growth (such as the nail bed), are normal.
Mutations in the RSPO4 gene cause anonychia congenita. The RSPO4 gene provides instructions for making a protein called R-spondin-4. R-spondin-4 plays a role in the Wnt signaling pathway, a series of steps that affect the way cells and tissues develop. Wnt signaling is important for cell division, attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities. During early development, Wnt signaling plays a critical role in the growth and development of nails. R-spondin-4 is active in the skeleton and contributes to limb formation, particularly at the ends of the fingers and toes where nail development occurs.
Anonychia congenita is a rare condition; its prevalence is unknown.
Anonychia congenita resulting from RSPO4 gene mutations is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Israel Englander Department Of Dermatology - Weill Greenberg Center
Shari Lipner is a Dermatologist practicing medicine in New York, New York. Dr. Lipner is rated as a Distinguished provider by MediFind in the treatment of Anonychia Congenita. She is also highly rated in 32 other conditions, according to our data. Her clinical expertise encompasses Ringworm, Autosomal Recessive Hypotrichosis, Anonychia Congenita, and Athlete's Foot.
Florida Medical Clinic Orlando Health
Rachel Careccia is a Dermatologist practicing medicine in Tampa, Florida. Dr. Careccia is rated as a Distinguished provider by MediFind in the treatment of Anonychia Congenita. She is also highly rated in 1 other condition, according to our data. Her clinical expertise encompasses Anonychia Congenita, Malignant Hypertension, Female Pattern Baldness, and Contact Dermatitis. Dr. Careccia is board certified in American Board Of Dermatology. Dr. Careccia is currently accepting new patients.
Dr. Wilson Liao specializes in caring for patients with psoriasis and other skin disorders that may respond to phototherapy (exposure to ultraviolet light). Liao is interested in bringing cutting-edge research technologies into patient care in the clinic, a field called translational medicine. He is involved in a number of research studies on new therapies for psoriasis and skin cancer, and welcomes patient inquiries on study participation. Liao earned his medical degree at Harvard Medical School. He completed both his residency and fellowship in dermatology at UCSF. Dr. Liao is rated as an Advanced provider by MediFind in the treatment of Anonychia Congenita. He is also highly rated in 14 other conditions, according to our data. His clinical expertise encompasses Psoriasis, Plaque Psoriasis, Atopic Dermatitis, Guttate Psoriasis, and Tissue Biopsy. Dr. Liao is board certified in American Board Of Dermatology, Dermatology.
Published Date: May 01, 2017
Published By: National Institutes of Health