Anonychia CongenitaSymptoms, Doctors, Treatments, Advances & More
Learn About Anonychia Congenita
Anonychia congenita is a condition that affects the fingernails and toenails. Individuals with this condition are typically missing all of their fingernails and toenails (anonychia). This absence of nails is noticeable from birth (congenital). In some cases, only part of the nail is missing (hyponychia) or not all fingers and toes are affected. All of the other tissues at the tips of the fingers and toes, including structures that usually support the nail and its growth (such as the nail bed), are normal.
Mutations in the RSPO4 gene cause anonychia congenita. The RSPO4 gene provides instructions for making a protein called R-spondin-4. R-spondin-4 plays a role in the Wnt signaling pathway, a series of steps that affect the way cells and tissues develop. Wnt signaling is important for cell division, attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities. During early development, Wnt signaling plays a critical role in the growth and development of nails. R-spondin-4 is active in the skeleton and contributes to limb formation, particularly at the ends of the fingers and toes where nail development occurs.
Anonychia congenita is a rare condition; its prevalence is unknown.
Anonychia congenita resulting from RSPO4 gene mutations is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Natalia Jaimes is a Dermatologist practicing medicine in Miami, Florida. Dr. Jaimes is rated as an Experienced provider by MediFind in the treatment of Anonychia Congenita. Her clinical expertise encompasses Actinic Keratosis, Melanoma, Liver Spots, and Universal Acquired Melanosis.
Florida Medical Clinic Orlando Health - Tampa - Dermatology
Dr. Rachel Careccia is a double board-certified dermatologist and dermatopathologist with Florida Medical Clinic Orlando Health. She has cared for patients in the Tampa Bay area since 2006, and her specialties include: Acne Rosacea Eczema Psoriasis Moles and birthmarks Skin cancer screening Dr. Careccia believes there is an inseparable link between skin health and systemic wellness. She is dedicated to providing personalized care that bridges the gap between high-level science and human connection. Dr. Careccia’s Training Dr. Careccia earned a bachelor’s degree in zoology at the University of Florida in Gainesville and received her medical degree from the University of Miami in Coral Gables, Florida. She completed a dermatology residency at Wake Forest University Baptist Medical Center in Winston-Salem, North Carolina, and a dermatopathology fellowship at the Medical University of South Carolina in Charleston. About Dr. Careccia She is board certified in dermatology and dermatopathology by the American Board of Dermatology. Her professional memberships include the American Academy of Dermatology, American Society of Dermatopathology, Society of Pediatric Dermatology and West Coast Florida Medical Society. Dr. Careccia’s research has been published in numerous peer-reviewed medical journals, and she serves as a reviewer for the Journal of Dermatological Treatment. Outside of work, she enjoys spending time with family, reading, mahjong and embroidery. Dr. Careccia is rated as a Distinguished provider by MediFind in the treatment of Anonychia Congenita. She is also highly rated in 1 other condition, according to our data. Her clinical expertise encompasses Anonychia Congenita, Female Pattern Baldness, Malignant Hypertension, and Contact Dermatitis. Dr. Careccia is board certified in American Board Of Dermatology and American Board Of Dermatology - Dermatopathology.
Israel Englander Department Of Dermatology - Weill Greenberg Center
Shari Lipner is a Dermatologist practicing medicine in New York, New York. Dr. Lipner is rated as a Distinguished provider by MediFind in the treatment of Anonychia Congenita. She is also highly rated in 34 other conditions, according to our data. Her clinical expertise encompasses Ringworm, Autosomal Recessive Hypotrichosis, Anonychia Congenita, and Athlete's Foot.
Published Date: May 01, 2017
Published By: National Institutes of Health