Mechanisms of Deep Transcranial Magnetic Stimulation Enhances the Efficacy of Cognitive-behavioral Therapy (CBT) by Modulating Anterior Cingulate Cortex in Patients With Anorexia Nervosa

Status: Recruiting
Location: See location...
Intervention Type: Other, Device, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if dTMS targeting the ACC can be used to rapidly and effectively treat AN. A randomized controlled study design is adopted, in which patients with AN are divided into the CBT+dTMS treatment group and CBT+pseudostimulation group by 1:1 randomization, followed by a 6-week intervention and a half-year follow-up to clarify whether CBT combined with dTMS is superior to single CBT treatment for AN.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 35
Healthy Volunteers: f
View:

• Female, aged 18-35 years, right handedness.

• Above primary education.

• Meet the diagnostic criteria of AN in DSM-V, and13.0 kg/m2 ≤ body mass index (BMI)\<18.5 kg/m2.

• No systemic nutritional therapy, psychiatric medication or any form of psychotherapy have been received within 1 month before enrollment.

• Able to understand the nature of this study and sign an informed consent form.

Locations
Other Locations
China
Shanghai Mental Health
RECRUITING
Shanghai
Contact Information
Primary
Jue Chen, PHD
chenjue2088@163.com
+8618017311203
Time Frame
Start Date: 2025-04-30
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 110
Treatments
Experimental: CBT+dTMS treatment group
CBT+dTMS treatment group has 55 patients. Each patient receives 12 individual sessions of CBT for 50 minutes 2 times per week for 6 weeks. dTMS intervention use real coils, targeting ACC, given 5 times per week (Monday to Friday) for 6 consecutive weeks.
Active_comparator: CBT+pseudo-stimulation group
CBT+Pseudo-stimulation group has 55 patients. Each patient receives 12 individual sessions of CBT for 50 minutes 2 times per week for 6 weeks. dTMS intervention uses sham coils (with the same parameters as real dTMS and generating the same noise as real coils, but without the magnetic field). It is given 5 times per week (Monday to Friday) for 6 consecutive weeks.
Related Therapeutic Areas
Sponsors
Leads: Shanghai Mental Health Center

This content was sourced from clinicaltrials.gov