Getting Into the Guts of Eating Disorders in Children and Adolescents. A Perspective From Psychoneuroimmunology.

Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY

The goal of this observational study is to learn if behavioral and psychological factors are associated with the intestinal microbiota composition and function in children and adolescents with eating disorders (ED). The main questions it aims to answer are: * Are there any differences between the microbiota composition and function in adolescent patients with eating disorders and healthy adolescents? * Are the dietary pattern and other lifestyle habits associated with the intestinal microbiota composition in patients with a recent onset eating disorder? * Is it possible to predict the treatment response at one year by looking at any of the psychological and biological factors measured in the patients at baseline? * Are there any differences in the intestinal microbiota among patients with different subtypes of anorexia nervosa (restrictive, binge-purging, atypical) or with avoidance/restrictive food intake disorder (ARFID)? Researchers will compare the results with those obtained from a group of healthy children and adolescents matched by sex and age to find out if the associations observed differ between ED and control participants. Participants with ED will fill in different lifestyle questionnaires and psychological tests; they will also undergo anthropometrical measurements and will provide fecal and blood samples at baseline and one year later. Healthy participants will provide the same lifestyle information, anthopometrical measurements and stool and blood samples. They will only undergo the baseline evaluation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 7
Maximum Age: 18
Healthy Volunteers: t
View:

• Age: 7-17.9 years

• Diagnosis of Anorexia Nervosa, both restrictive (ANR) and binge-purging (ANBP) subtypes, Other Specified Feeding and Eating Disorders (OSFED), Avoidant/Restrictive Food Intake Disorder (ARFID) according to DSM-V (APA, 2013).

• Males and females

• First episode or less than 1 year evolution since initial symptoms

• Written informed consent by parent/tutor and also by the adolescent if age is more than 12 y.

Locations
Other Locations
Spain
Hospital Infantil Universitario Niño Jesús
RECRUITING
Madrid
Institute of Food Science and Technology and Nutrition (ICTAN, CSIC)
RECRUITING
Madrid
Contact Information
Primary
Esther Nova, PhD
enova@ictan.csic.es
34 5492300
Time Frame
Start Date: 2024-08-29
Estimated Completion Date: 2027-08
Participants
Target number of participants: 158
Treatments
Eating disorder patients
Children and adolescents with a recent onset eating disorder initiating treatment in a Specialized Eating Disorder Unit
Control group
Healthy children and adolescents matched by age and sex with the ED patients
Related Therapeutic Areas
Sponsors
Collaborators: FUNDACION PARA LA INVESTIGACIÓN BIOMÉDICA HOSPITAL INFANTIL UNIVERSITARIO NIÑO JESUS, Spanish National Research Council (ICTAN, CSIC)
Leads: Esther Nova

This content was sourced from clinicaltrials.gov