Learn About Antiphospholipid Syndrome

What is the definition of Antiphospholipid Syndrome?

Antiphospholipid syndrome is a disorder characterized by an increased tendency to form abnormal blood clots (thromboses) that can block blood vessels. This clotting tendency is known as thrombophilia. In antiphospholipid syndrome, the thromboses can develop in nearly any blood vessel in the body. If a blood clot forms in the vessels in the brain, blood flow is impaired and can lead to stroke. Antiphospholipid syndrome is an autoimmune disorder. Autoimmune disorders occur when the immune system attacks the body's own tissues and organs.

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What are the causes of Antiphospholipid Syndrome?

The genetic cause of antiphospholipid syndrome is unknown. This condition results from the presence of three abnormal immune proteins (antibodies) in the blood. The antibodies that cause antiphospholipid syndrome are called lupus anticoagulant, anticardiolipin, and anti-B2 glycoprotein I. These antibodies are referred to as antiphospholipid antibodies. People with this condition can test positive for one, two, or all three antiphospholipid antibodies in their blood. Antibodies normally attach (bind) to specific foreign particles and germs, marking them for destruction, but the antibodies in antiphospholipid syndrome attack normal human proteins. When these antibodies attach to proteins, the proteins change shape and attach to other molecules and receptors on the surface of cells. Attaching to cells, particularly immune cells, turns on (activates) the blood clotting pathway and other immune responses.

How prevalent is Antiphospholipid Syndrome?

Antiphospholipid syndrome is estimated to affect 1 in 2,000 people. This condition may be responsible for up to one percent of all thromboses. It is estimated that 20 percent of individuals younger than age 50 who have a stroke have antiphospholipid syndrome. Ten to 15 percent of people with systemic lupus erythematosus have antiphospholipid syndrome. Similarly, 10 to 15 percent of women with recurrent miscarriages likely have this condition. Approximately 70 percent of individuals diagnosed with antiphospholipid syndrome are female.

Is Antiphospholipid Syndrome an inherited disorder?

Most cases of antiphospholipid syndrome are sporadic, which means they occur in people with no history of the disorder in their family. Rarely, the condition has been reported to run in families; however, it does not have a clear pattern of inheritance. Multiple genetic and environmental factors likely play a part in determining the risk of developing antiphospholipid syndrome.

Who are the top Antiphospholipid Syndrome Local Doctors?
Highly rated in

University Of Turin

Grugliasco, IT 10095

Savino Sciascia is in Grugliasco, Italy. Sciascia is rated as an Elite expert by MediFind in the treatment of Antiphospholipid Syndrome. He is also highly rated in 20 other conditions, according to our data. His top areas of expertise are Antiphospholipid Syndrome, Systemic Lupus Erythematosus, Glomerulonephritis, and Vasculitis.

Highly rated in

University Of Padua

Padova, IT 

Vittorio Pengo is in Padova, Italy. Pengo is rated as an Elite expert by MediFind in the treatment of Antiphospholipid Syndrome. They are also highly rated in 11 other conditions, according to our data. Their top areas of expertise are Antiphospholipid Syndrome, Mesenteric Venous Thrombosis, Atrial Fibrillation, and Venous Thromboembolism.

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Highly rated in

Université De Lorraine

Inserm, Dcac, Vascular Medicine Division And Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases 
Nancy, FR 54000

Stephane Zuily is in Nancy, France. Zuily is rated as an Elite expert by MediFind in the treatment of Antiphospholipid Syndrome. She is also highly rated in 7 other conditions, according to our data. Her top areas of expertise are Antiphospholipid Syndrome, Factor V Leiden Thrombophilia, Systemic Lupus Erythematosus, and Mesenteric Venous Thrombosis.

What are the latest Antiphospholipid Syndrome Clinical Trials?
A Pilot Study of Telitacicept Treatment in Primary APS Patients
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The APSantiCo Observational Study - Prospective Observational Study to Evaluate a Possible Change in APS Antibody Profiles After COVID-19 Infection or Vaccination
Who are the sources who wrote this article ?

Published Date:updated Last, March

Published By: National Institutes of Health

What are the Latest Advances for Antiphospholipid Syndrome?
Sirolimus Monotherapy for Thrombocytopenia in Primary Antiphospholipid Syndrome: A Pilot Study From a Tertiary Referral Center.
Recurrent strokes and memory loss in a patient with triple-positive antiphospholipid antibody syndrome.
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Levothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.