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Learn About Antisynthetase Syndrome

What is the definition of Antisynthetase Syndrome?
Antisynthetase syndrome is a chronic autoimmune condition that affects the muscles and various other parts of the body. The signs and symptoms can vary but may include muscle inflammation (myositis), polyarthritis (inflammation of many joints), interstitial lung disease, thickening and cracking of the hands, and Raynaud phenomenon. The exact underlying cause is unknown; however, the production of autoantibodies (antibodies that attack normal cells) that attack certain enzymes in the body called 'aminoacyl-tRNA synthetases' appears to be linked to the cause of the syndrome. These autoantibodies may arise after viral infections, or patients may have a genetic predisposition.
What are the alternative names for Antisynthetase Syndrome?
  • Antisynthetase syndrome
  • AS syndrome
  • Anti-Jo1 syndrome
Who are the top Antisynthetase Syndrome Local Doctors?
Ann M. Reed
Rheumatology | General Practice
Rheumatology | General Practice

Duke University School Of Medicine

2301 Erwin Rd, Box 3352, 
Durham, NC 
 53.0 mi
Recognized by The Myositis Association
Accepting New Patients
Offers Telehealth

Ann Reed is a General Practice specialist and a Rheumatologist in Durham, North Carolina. Dr. Reed and is rated as an Experienced provider by MediFind in the treatment of Antisynthetase Syndrome. Her top areas of expertise are Juvenile Dermatomyositis, Dermatomyositis, Myositis, and Polymyositis. Dr. Reed is currently accepting new patients.

Rheumatology
Rheumatology

Arthritis And Osteoporosis Consultant Carolinas PA

1918 Randolph Road, Suite 600, 
Charlotte, NC 
 80.1 mi
Accepting New Patients
Offers Telehealth

Gordon Lam is a Rheumatologist in Charlotte, North Carolina. Dr. Lam and is rated as a Distinguished provider by MediFind in the treatment of Antisynthetase Syndrome. His top areas of expertise are Eosinophilia-Myalgia Syndrome, Antisynthetase Syndrome, Dermatomyositis, and Rheumatoid Arthritis (RA). Dr. Lam is currently accepting new patients.

 
 
 
 
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Rheumatology
Rheumatology

Carolina Rheumatology And Internal Medicine PA

2125 Valleygate Dr, Suite 201, 
Fayetteville, NC 
 35.5 mi
Accepting New Patients
Offers Telehealth

Sanjay Garg is a Rheumatologist in Fayetteville, North Carolina. Dr. Garg and is rated as a Distinguished provider by MediFind in the treatment of Antisynthetase Syndrome. His top areas of expertise are Eosinophilia-Myalgia Syndrome, Antisynthetase Syndrome, Rheumatoid Arthritis (RA), and Lupus Nephritis. Dr. Garg is currently accepting new patients.

What are the latest Antisynthetase Syndrome Clinical Trials?
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, 2-Arm, Multicenter, Operationally Seamless Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Participants Aged 18 Years and Older with Active Idiopathic Inflammatory Myopathy

Summary: This study's purpose is to measure the treatment response from efgartigimod PH20 SC compared with placebo in participants with Idiopathic Inflammatory Myopathy (IIM). Participants with the IIM subtypes of dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), or certain other subtypes of polymyositis (PM; including antisynthetase syndrome \[ASyS\]) will be included in the study. Treatm...

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Evaluation of Antigen-specific Th1 and T17 Cells, ILC and MAIT in Patients With Antisynthetase Syndrome and Interstitial Lung Disease

Summary: Antisynthetase syndrome (AS) is a rare overlapping myositis characterized by cellular and humoral autoimmune responses directed against aminoacyl-tRNA synthetases. Intesrtitial lung disease (ILD) is a leading cause of mortality in antisynthetase syndrome. Recently, antigen-specific IFN-γ+ CD4+ T cells have been identified in bronchoalveolar fluid (BAL) of patients with antisynthetase syndrome and ...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center