Effect of Visual Retraining on Visual Loss Following Cortical Damage

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and brain function. The investigators will also assess the effect of intensive visual retraining on the residual visual system, processing of visual information and the use of such information in real-world situations following damage. This research is intended to improve our understanding of the consequences of permanent visual system damage in humans, of methods that can be used to reverse visual loss, and of brain mechanisms by which visual recovery is achieved.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 80
Healthy Volunteers: t
View:

• Between 21 and 80 years of age

• Residents of the United States or Canada

• Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range (21-75 years)

• Reliable visual field defects in both eyes as measured by Humphrey, MAIA, Goldmann, and/or equivalent perimetry, large enough to enclose a 5-deg diameter visual stimulus.

• Able to fixate on visual targets reliably for 1000ms

• Must have a home computer (desktop or laptop) and reliable internet access

• Willing, able, and competent to provide informed consent

• Normal cognitive abilities, able to understand written and oral instructions in English, and competent and responsible adults in order to complete the visual training at home, independently, as instructed, for several months.

• Between 21 and 80 years of age

• Report no history of neurological disorder.

• Competent and responsible, as determined by the Principal Investigator.

Locations
United States
New York
University of Rochester Medical Center
RECRUITING
Rochester
Contact Information
Primary
Evan Burr
Evan_Burr@urmc.rochester.edu
585-275-5234
Time Frame
Start Date: 2024-09-05
Estimated Completion Date: 2032-01
Participants
Target number of participants: 100
Treatments
Experimental: Experimental: Cortically Blind (CB) Subjects
Cortically Blind subjects will be enrolled to perform a daily home visual training task.
No_intervention: Normative Comparator: Control Subjects
Healthy control subjects will be recruited to collect normative data by which to compare test results from CB subjects. No home training will be asked.
Related Therapeutic Areas
Sponsors
Leads: University of Rochester

This content was sourced from clinicaltrials.gov

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