Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department: the Aggrecan, Desmosine, D-dimer-Emergency Department (ADD-ED) Study
The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are: * To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection * To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection * To study the association between plasma levels of selected biomarkers and clinical outcomes
• Age ≥ 18 years
• Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit
• Confirmed AD
‣ the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first
⁃ The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery.