Efficacy of Nitric Oxide Administration for Reducing the Risk of Acute Kidney Injury in Patients with Acute Type a Aortic Dissection: a Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The goal of this clinical trial is to determine the effectiveness of exogenous nitric oxide therapy in reducing the occurrence of acute kidney injury in patients with acute type A aortic dissection. Additionally, it aims to assess the safety of exogenous nitric oxide therapy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Provide written informed consent;
• Participants must be over 18 years of age;
• Participants should meet the diagnostic and treatment guidelines for thoracic aortic diseases jointly issued by ACC/AHA in 2022, have received clinical and radiological diagnosis of acute type A aortic dissection, and undergone surgical thoracotomy within two weeks after symptom onset.
Locations
Other Locations
China
Beijing Anzhen Hospital
RECRUITING
Beijing
Time Frame
Start Date: 2024-11-30
Estimated Completion Date: 2026-06-01
Participants
Target number of participants: 216
Treatments
Experimental: Nitric Oxide
Patients in this group receive treatment with exogenous nitric oxide (NO) via the CPB machine. After CPB, NO is administered through the inspiratory limb of the anesthetic or ventilator circuit and then via the mechanical ventilator in the ICU. Once patients are extubated, they will breathe NO through a facemask or nasal cannula. NO administration begins at the start of CPB and continues for 12 hours post-operation.
Placebo_comparator: Usual care
Patients in this group receive a sham treatment without the supply of nitric oxide during CPB and for 12 hours post-operation.
Related Therapeutic Areas
Sponsors
Leads: Beijing Anzhen Hospital