Nordic Multicenter Study of Risk Factors, Surgical Treatment and Outcomes in Acute Type a Aortic Dissection

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

The Nordic Consortium for Acute Type A Aortic Dissection-2 (NORCAAD-2) is a multicenter research collaboration involving up to 19 units in the Nordic countries and one in The Netherlands. All patients referred for this condition is included, to outline detailed preoperative characteristics and risk factors as well as, for those operated, data on the operative procedure, the postoperative course including major and minor complications and, as the primary interest, mortality in short- and long-term perspective. The need for further procedures on the aorta will also be studied. Acute type A Aortic Dissection (ATAAD) is a vascular emergency with very high case-fatality rate. The condition is realtively infrequent, and single units can rarely amass sufficient number of patients during a reasonable time to analyse also unusual variants in background, presentation, and management. Randomized controlled trials are unlikely, and large multicenter databases are the best source of knowledge for the foreseeable future. Other such databases exist, but NORCAAD-2 is more focused (only ATAAD) and more detailed than many counterparts, with the ability to extract unique information. NORCAAD-2 is the extension and expansion of the original NORCAAD project. NORCAAD-2 includes more centers, more patients, more data and utilizes a novel on-line common database designed for the purpose. The ultimate goal is to identify novel risk markers to help inform decisions on pre-emptive surgery (before ATAAD occurs); to outline superior perioperative techniques and strategies to optimize outcomes both short- and long-term; and to analyze variables related to major complications, in an effort to further reduce their incidence.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Acute (within 14 days of onset) type A aortic dissection or similar acute aortic syndrome

Locations
Other Locations
Sweden
Karolinska Institute
RECRUITING
Stockholm
Contact Information
Primary
Christian Olsson, MD, PhD
christian.olsson@ki.se
+46812370000
Backup
Markus Bjurbom, MD
markus.bjurbom@ki.se
+46812370000
Time Frame
Start Date: 2019-06-03
Estimated Completion Date: 2030-06
Participants
Target number of participants: 5000
Related Therapeutic Areas
Sponsors
Collaborators: Tampere University Hospital, Odense University Hospital, Uppsala University Hospital, Helsinki University Central Hospital, Vastra Gotaland Region, Skane University Hospital, Leiden University Medical Center, Norrlands University Hospital, Haukeland University Hospital, Landspitali University Hospital, Trondheim University Hospital, University Hospital, Linkoeping, Oslo University Hospital, Turku University Hospital, Örebro University, Sweden, Kuopio University Hospital, Blekinge County Council Hospital, Aarhus University Hospital Skejby, Rigshospitalet, Denmark
Leads: Karolinska Institutet

This content was sourced from clinicaltrials.gov

Similar Clinical Trials