∙ Subjects must meet the following criteria to be included in the study:

• Subject has moderate or greater aortic stenosis or regurgitation, and there is a clinical indication for replacement of their native or prosthetic aortic valve with a bioprosthesis, with or without concomitant procedures, which are limited to any of the following:

‣ Atrial fibrillation (AF) ablation

⁃ Ascending aortic aneurysm or dissection repair or replacement, with or without circulatory arrest

⁃ Coronary artery bypass graft (CABG)

⁃ Surgical management of the left atrial appendage (LAA)

⁃ Patent foramen ovale (PFO) closure

⁃ Resection of a sub-aortic membrane not requiring myectomy

• Subject is geographically stable and willing to return to the implanting site for all follow-up visits

• Subject is of legal age to provide informed consent

• Subject has been adequately informed of risks and requirements of the study and is willing and able to provide informed consent for participation in the study