Association of Lipoprotein(a) With Progression of Degenerative Aortic Valve Stenosis: Propensity-matched Study

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

This study is a prospective, observational, two arm parallel group, clinical study involving patients with measurements of Lp(a) and mild to moderate aortic stenosis. A total of 1381 patients underwent measurement of Lp(a) and had a diagnosis of mild to moderate, degenerative aortic stenosis between 2001 and 2020 in Asan Medical Center. Investigators selected a propensity-matched cohort of patients with Lp(a) \>70 mg/dL and those with Lp(a) \<30 mg/dL from the registry of patients with mild to moderate aortic stenosis to control risk factors for progression of aortic stenosis, and try to prospectively compare progression of aortic stenosis between the two groups (Lp(a) \>70 mg/dL versus Lp(a) \< 30 mg/dL). Investigators also evaluate interactions between Lp(a) groups and baseline clinical and echocardiographic variables for progression of aortic stenosis.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Mild to moderate degenerative AVS Aortic peak velocity greater than 2 m/s and smaller than 4 m/s

• LP(a) \>70 mg/dL or \<30 mg/dL

• Patients must provide written informed consent

Locations
Other Locations
Republic of Korea
Asan Medical Center
RECRUITING
Seoul
Contact Information
Primary
Ka-Yoon Kim, MD
kimgy741@naver.com
82-2-3010-1222
Time Frame
Start Date: 2025-02-10
Estimated Completion Date: 2025-12
Participants
Target number of participants: 364
Treatments
Patients with mild to moderate AVS
Patients with measurements of Lp(a) and mild to moderate AVS
Related Therapeutic Areas
Sponsors
Leads: Asan Medical Center

This content was sourced from clinicaltrials.gov

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