Apolipoprotein C2 DeficiencySymptoms, Doctors, Treatments, Advances & More
Apolipoprotein C2 Deficiency Overview
Learn About Apolipoprotein C2 Deficiency
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Joseph Witztum is an Endocrinologist in La Jolla, California. Dr. Witztum is rated as an Elite provider by MediFind in the treatment of Apolipoprotein C2 Deficiency. His top areas of expertise are Apolipoprotein C2 Deficiency, Familial Lipoprotein Lipase Deficiency, Familial Hypertriglyceridemia, and Antigen-Peptide-Transporter 2 Deficiency.
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Sotirios Tsimikas is a Cardiologist in La Jolla,, California. Dr. Tsimikas is rated as an Elite provider by MediFind in the treatment of Apolipoprotein C2 Deficiency. His top areas of expertise are High Cholesterol, Apolipoprotein C2 Deficiency, Familial Lipoprotein Lipase Deficiency, Percutaneous Coronary Intervention (PCI), and Stent Placement.
Baylor Medicine Atherosclerosis
Christie Ballantyne is a Cardiologist in Houston, Texas. Dr. Ballantyne is rated as an Elite provider by MediFind in the treatment of Apolipoprotein C2 Deficiency. His top areas of expertise are Familial Hypertriglyceridemia, High Cholesterol, Atherosclerosis, Coronary Artery Bypass Graft (CABG), and Heart Bypass Surgery.
Summary: This is an open-label, single-arm, dose-escalation Phase I clinical trial to evaluate the safety, tolerability, pharmacodynamics (PD), and pharmacokinetics (PK) of CS-121, an in vivo base editing therapy delivered by lipid nanoparticles targeting APOC3, in adult participants (18-55 years) with familial chylomicronemia syndrome (FCS).
Summary: Lipoprotein lipase (LPL) is an enzyme that plays an important role in removing triglycerides (TG) (molecules that transport dietary fat) from the blood. Patients with LPL deficiency (LPLD) display during their whole life very high plasma TG levels often associated with episodes of postprandial abdominal pain, malaise, blurred vision, dizziness (hyperchylomicronemia syndrome) that may lead to recur...