Condition 101

What is the definition of Arachnoiditis?

Arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. The inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or ...

For more information, visit GARD

What are the alternative names for Arachnoiditis?

  • Spinal arachnoiditis

What are the causes for Arachnoiditis?

Arachnoiditis has many possible causes, including:
  • mechanical injury during spinal surgery, or complications from spinal surgery (about 60% of cases)
  • trauma to the spinal cord
  • one or more spinal taps
  • steroid epidural injections or other injections
  • spinal and epidural anesthesia
  • myelography
  • bacterial or viral spinal infections
The initial symptoms of arachnoiditis are caused by inflammation of the arachnoid, and the formation of scar tissue and adhesions later cause the more severe symptoms as the condition progresses.

What are the symptoms for Arachnoiditis?

Arachnoiditis can cause a number of symptoms including numbness; tingling; loss of temperature sensation; and a characteristic stinging and burning pain in the lower back, limbs, and trunk. Pain is often made worse by activity. Some people have debilitating muscle cramps or spasms; loss of balance; tinnitus; problems with vision and hearing; or bladder, bowel, or sexual dysfunction. In severe cases, arachnoiditis may lead to paralysis of the legs.

What are the current treatments for Arachnoiditis?

Arachnoiditis is difficult to treat. Management aims to relieve pain and improve symptoms that impair fuction. Treatment may involve pain management, physical therapy, and psychotherapy. Surgical intervention is controversial because it generally provides only short-term relief and may increase the formation of scar tissue, making the condition worse.

What is the outlook (prognosis) for Arachnoiditis?

Arachnoiditis causes chronic pain and neurological deficits. The disease does not improve significantly with treatment and does not have a predictable pattern of symptoms, severity, or progression. Some people with arachnoiditis may have milder symptoms which do not get much worse over time, although the aging process usually does add to the severity of the symptoms.  Others may quickly progress to severe neurological symptoms that lead to paralysis. The majority of people with arachnoiditis appear to fall somewhere between these extremes. 

Is Arachnoiditis an inherited disorder?

Arachnoiditis is generally not an inherited condition and typically results from inflammation due to prior spinal surgery, other procedures on the spine (such as injections), trauma, or infection. Familial cases of arachnoiditis have very rarely been reported. To our knowledge, only two families with multiple affected family members have been described in the literature, with possible autosomal dominant or multigenic inheritance (due to the interaction of multiple genes).

Latest Research

Latest Advance
  • Condition: Subarachnoid Neurocysticercosis (SUBNCC)
  • Journal: The American journal of tropical medicine and hygiene
  • Treatment Used: Extended Cysticidal and Anti-Inflammatory Regimens
  • Number of Patients: 34
  • Published —
This article describes the natural history of treated subarachnoid neurocysticercosis (parasitic infection; SUBNCC).
Latest Advance
  • Condition: Syringomyelia Associated with Extensive Spinal Adhesive Arachnoiditis (SAA)
  • Journal: World neurosurgery
  • Treatment Used: Syringoperitoneal Shunting with a Programmable Shunt Valve
  • Number of Patients: 15
  • Published —
This study verified the safety and effectiveness of syringoperitoneal shunting for syringomyelia associated with extensive spinal adhesive arachnoiditis (SAA).
Latest Advance
  • Condition: Escherichia coli meningitis in infants
  • Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • Treatment Used: Combination therapy with ciprofloxacin and third-generation cephalosporin versus third-generation cephalosporin alone
  • Number of Patients: 367
  • Published —
The study compared the outcomes of a combination therapy with ciprofloxacin and third-generation cephalosporin versus third-generation cephalosporin alone for treating Escherichia coli meningitis in infants.
Latest Advance
  • Condition: Diffuse Spinal Arachnoiditis (SA) after Complicated Vertebral Artery Dissection
  • Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • Treatment Used: Posterior Fusion, Decompression, and Shunt
  • Number of Patients: 1
  • Published —
This case report discusses a middle-aged woman who developed a rare case of diffuse spinal arachnoiditis (SA) following a complicated vertebral artery dissection treated with posterior (T4-T8) spinal fusion and (T5-T7) decompression with arachnoid-cyst fenestration and placement of a subarachnoid-pleural shunt.

Clinical Trials

There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.