Pain Processing Mechanisms in Patients With Juvenile Arthritis

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in children. The main symptoms of JIA, which are often the primary focus of treatment, include joint swelling, stiffness, and tenderness. Additional symptoms can include malaise, fatigue, and pain. However, the exact mechanisms contributing to pain are not yet fully understood. Participants will complete a 2.5-hours study session. In the study session, psychophysical assessments of thermal and pressure stimuli will be performed. In addition, demographic, social, pubertal maturation, and behavioral and psychological factors will be collected via questionnaires. A saliva sample and/or blood draw may occur for the analysis of various immune factors and sex hormones. If a joint aspiration is done as part of their standard of care, we will request a sample of the synovial fluid for analyses of immune, hormonal and/or genetic factors. Participants will have the option to participate in additional optional follow-up study visits (every 3 months, up to 1 year) and to complete monthly surveys asking about their juvenile arthritis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 9
Maximum Age: 17
Healthy Volunteers: t
View:

• Age between 9-17

• Males and females

• English speakers

• Able to complete surveys and understand study instructions

• Juvenile arthritis group: diagnosed or suspected of juvenile arthritis

• Control group: healthy

Locations
United States
Missouri
Washington University School of Medicine
RECRUITING
St Louis
Contact Information
Primary
Alana McMichael, MA
painlab@wustl.edu
314-273-6194
Time Frame
Start Date: 2025-09-15
Estimated Completion Date: 2035-09
Participants
Target number of participants: 140
Treatments
Other: JIA
Inclusion:~1. Age between 9-17~2. Males and females~3. English speakers~4. Able to complete surveys and understand study instructions~5. Diagnosed or suspected of juvenile arthritis~Exclusion Criteria~Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:~1. Pregnancy or breastfeeding~2. (Control Group) Diagnosed with a chronic pain condition~3. (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.
Other: Controls
Inclusion:~1. Age between 9-17~2. Males and females~3. English speakers~4. Able to complete surveys and understand study instructions~5. Healthy~Exclusion Criteria~Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:~1. Pregnancy or breastfeeding~2. (Control Group) Diagnosed with a chronic pain condition~3. (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.
Sponsors
Leads: Washington University School of Medicine

This content was sourced from clinicaltrials.gov