Postoperative Analgesia in Patients Undergoing Knee Replacement Surgery - a Study Comparing Intraoperative Local Infiltration Analgesia Only With Ultrasound-guided Nerve Blocks Added to Intraoperative Local Infiltration Analgesia, a Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral cutaneous nerve (AFCN) block in participants undergoing total knee arthroplasty (TKA). The primary outcome is pain intensity, measured using the Numerical Rating Scale (NRS) at multiple time points after surgery. Secondary outcomes include opioid consumption, time to mobilization, postoperative nausea and vomiting, length of hospital stay, neurological complications and differences in opioid consumption and NRS pain scores between general and spinal anesthesia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Undergoing primary unilateral total knee arthroplasty
Locations
Other Locations
Sweden
Department of Anaesthesiology, Trelleborg Hospital
RECRUITING
Trelleborg
Contact Information
Primary
Fredrik Fellert, MD
fredrik.fellert@med.lu.se
+46736552249
Backup
Andreas Ekman, MD, PhD
andreas.ekman@med.lu.se
+46702542552
Time Frame
Start Date: 2026-03-05
Estimated Completion Date: 2027-09-01
Participants
Target number of participants: 200
Treatments
Active_comparator: Intervention Arm-Nerve blocks in addition to Local Infiltration Analgesia
Ultrasound guided nerve blocks are administered preoperatively in addition to the Local Infiltration Analgesia administered during surgery.~Nerve blocks used:~1. Nerve to Vastus Medialis (NVM) block:~ Injection: 5 ml ropivacaine 5% with clonidine 1.875 micrograms per ml~2. Saphenous Nerve (SN) block:~ Injection: 10 ml ropivacaine 0.5% with clonidine 1.875 micrograms per ml~3. Anterior Femoral Cutaneous Nerve (AFCN) Block:~AFCN divides into multiple branches at the level of the femoral triangle Injection: 1 ml ropivacaine 5% with clonidine 1.875 micrograms per ml per branch~Local Infiltration Analgesia (LIA):~150 ml ropivacaine 2 mg/ml with 0.5 mg adrenaline is infiltrated periarticular around the knee capsule, collateral ligaments, under the patella, and subcutaneously
No_intervention: Control arm - Local Infiltration Analgesia only
No ultrasound guided nerve blocks are administered. Local Infiltration Analgesia (LIA) is the same as in the- intervention arm:~150 ml ropivacaine 2 mg/ml with 0.5 mg adrenaline is infiltrated periarticular around the knee capsule, collateral ligaments, under the patella, and subcutaneously
Related Therapeutic Areas
Sponsors
Collaborators: Greta and Johan Kock Foundation
Leads: Region Skane