iPACK Block With Adductor Canal Block Mitigates Surgical Stress and Enhances Analgesia in Total Hip Arthroplasty: A Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This randomized controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SII, calculated as platelet × neutrophil / lymphocyte count, is used as a composite marker of perioperative inflammatory and immune response. The study investigates whether iPACK block with ACB attenuates the systemic inflammatory reaction to surgical trauma compared to sham block.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 100
Healthy Volunteers: f
View:
• Patients with ASA classification I-III
• Aged 65-100 years
• Who will be scheduled for hip arthroplasty under spinal anesthesia
Locations
Other Locations
Poland
Poznan University of Medical Sciences
RECRUITING
Poznan
Contact Information
Primary
Malgorzata Reysner, MD PhD
mreysner@ump.edu.pl
+48 501 056 924
Backup
Malgorzata Reysner, MD PhD
mreysner@ump.edu.pl
+48 61 83 10 122
Time Frame
Start Date: 2026-03-01
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 60
Treatments
Placebo_comparator: Sham blocks
iPACK block with 20ml of 0.9% sodium chloride and ACB with 20ml of 0.9% sodium chloride
Active_comparator: iPACK block with ACB
iPACK block with 20ml of 0.2% ropivacaine and ACB with 20ml of 0.2% ropivacaine
Related Therapeutic Areas
Sponsors
Leads: Poznan University of Medical Sciences