The Relationship of Quadriceps Muscle Echogenicity and Thickness Change During Isometric Contraction With Pain, Function, Quality of Life, and Patient Global Assessment in Knee Osteoarthritis
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The purpose of this cross-sectional, observational study is to evaluate the relationship between quadriceps muscle quality-specifically muscle echogenicity and thickness change during isometric contraction-and clinical outcomes such as pain, physical function, quality of life, and Patient Global Assessment (PtGA) in female patients with knee osteoarthritis. Participants will undergo a non-invasive ultrasound evaluation of their thigh muscles and complete standard clinical questionnaires to help determine how muscle structural and functional properties impact the daily lives of patients with knee osteoarthritis.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 40
Maximum Age: 70
Healthy Volunteers: t
View:
• Female sex
• Aged between 40 and 70 years
• Diagnosed with clinical and radiographic primary knee osteoarthritis (Kellgren-Lawrence Grade 2 or 3)
• Ability to perform isometric contraction at 90° of knee flexion
• Voluntary participation and provision of written informed consent
Locations
Other Locations
Turkey
Izmir Cıty Hospital
RECRUITING
Izmir
Contact Information
Primary
Halil İbrahim Candal
hibrahim.09@outlook.com
+905533789315
Time Frame
Start Date:2026-04-14
Estimated Completion Date:2026-12
Participants
Target number of participants:58
Treatments
Female Patients with Knee Osteoarthritis
This group consists of female patients aged 40-70 years diagnosed with primary knee osteoarthritis (Kellgren-Lawrence Grade 2 and 3) according to the American College of Rheumatology (ACR) criteria. All participants in this cohort will undergo:~1. Ultrasonographic Assessment: Measurement of Rectus Femoris and Vastus Intermedius muscle thickness at rest and during maximum voluntary isometric contraction, along with muscle echogenicity analysis.~2. Clinical Evaluation: Assessment of pain intensity via Visual Analog Scale (VAS), and evaluation of functional status and quality of life using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Patient Global Assessment (PtGA).
Healthy Control Group
This group consists of healthy female volunteers aged 40-70 years with no clinical or radiographic evidence of knee osteoarthritis and no history of chronic knee pain. Participants in this control group will undergo the same standardized evaluation protocol as the patient group to provide baseline values for:~1. Ultrasonographic Assessment: Measurement of Rectus Femoris and Vastus Intermedius muscle thickness at rest and during maximum voluntary isometric contraction, along with muscle echogenicity analysis.~2. Clinical Evaluation: Assessment of pain intensity via Visual Analog Scale (VAS), and evaluation of functional status and quality of life using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and Patient Global Assessment (PtGA).