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Condition

Asherman Syndrome

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Asherman Syndrome?

Asherman syndrome is the formation of scar tissue in the uterine cavity. The problem most often develops after uterine surgery.

What are the alternative names for Asherman Syndrome?

Uterine synechiae; Intrauterine adhesions; Infertility - Asherman

What are the causes for Asherman Syndrome?

Asherman syndrome is a rare condition. In most cases, it occurs in women who have had several dilatation and curettage (D&C) procedures.

A severe pelvic infection unrelated to surgery may also lead to Asherman syndrome.

Adhesions in the uterine cavity can also form after infection with tuberculosis or schistosomiasis. These infections are rare in the United States. Uterine complications related to these infections are even less common.

What are the symptoms for Asherman Syndrome?

The adhesions may cause:

  • Amenorrhea (lack of menstrual periods)
  • Repeated miscarriages
  • Infertility

However, such symptoms could be related to several conditions. They are more likely to indicate Asherman syndrome if they occur suddenly after a D&C or other uterine surgery.

What are the current treatments for Asherman Syndrome?

Treatment involves surgery to cut and remove the adhesions or scar tissue. This can most often be done with hysteroscopy. This uses small instruments and a camera placed into the uterus through the cervix.

After scar tissue is removed, the uterine cavity must be kept open while it heals to prevent adhesions from returning. Your health care provider may place a small balloon inside the uterus for several days. You may also need to take estrogen while the uterine lining heals.

You may need to take antibiotics if there is an infection.

What are the support groups for Asherman Syndrome?

The stress of illness can often be helped by joining a support group. In such groups, members share common experiences and problems.

What is the outlook (prognosis) for Asherman Syndrome?

Asherman syndrome can often be cured with surgery. Sometimes more than one procedure will be necessary.

Women who are infertile because of Asherman syndrome may be able to have a baby after treatment. Successful pregnancy depends on the severity of Asherman syndrome and the difficulty of the treatment. Other factors that affect fertility and pregnancy may also be involved.

What are the possible complications for Asherman Syndrome?

Complications of hysteroscopic surgery are uncommon. When they occur, they may include bleeding, perforation of the uterus, and pelvic infection.

In some cases, treatment of Asherman syndrome will not cure infertility.

When should I contact a medical professional for Asherman Syndrome?

Call your provider if:

  • Your menstrual periods do not return after a gynecologic or obstetrical surgery.
  • You cannot get pregnant after 6 to 12 months of trying (See a specialist for an infertility evaluation).

How do I prevent Asherman Syndrome?

Most cases of Asherman syndrome cannot be predicted or prevented.

Uterus
Normal

REFERENCES

Brown D, Levine D. The uterus. In: Rumack CM, Levine D, eds. Diagnostic Ultrasound. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 15.

Dolan MS, Hill C, Valea FA. Benign gynecologic lesions: vulva, vagina, cervix, uterus, oviduct, ovary, ultrasound imaging of pelvic structures. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 18.

Keyhan S, Muasher L, Muasher SJ. Spontaneous abortion and recurrent pregnancy loss: etiology, diagnosis, treatment. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 16.

Williams Z, Scott JR. Recurrent pregnancy loss. In: Resnik R, Lockwood CJ, Moore TR, Greene MF, Copel JA, Silver RM, eds. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2019:chap 44.

Latest Research

Latest Advance
Study
  • Condition: Caesarean Scar Pregnancy (CSP)
  • Journal: European journal of obstetrics, gynecology, and reproductive biology
  • Treatment Used: Selective Chemoembolization with Methotrexate (SCEM) Followed by Suction Curettage (SC)
  • Number of Patients: 22
  • Published —
This study assessed the effectiveness, complications and reproductive outcome of selective chemoembolization with methotrexate (SCEM) followed by suction curettage (SC) in the treatment of caesarean scar pregnancy (CSP).
Latest Advance
Study
  • Condition: Prevention of Recurrence of Intrauterine Adhesion after Hysteroscopic Adhesiolysis
  • Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • Treatment Used: Amniotic Membrane
  • Number of Patients: 300
  • Published —
This review of the literature evaluated the ability of amniotic membrane to prevent the recurrence of intrauterine adhesion after hysteroscopic adhesiolysis (removal of adhesion).

Clinical Trials

Clinical Trial
Procedure
  • Status: Recruiting
  • Study Type: Procedure
  • Participants: 40
  • Start Date: September 30, 2020
Cervico-Isthmic Compression Suture Versus Anterior Wall Uterine Resection in Cases of Morbidly Adherent Anterior Situated Placenta
Clinical Trial
Biological
  • Status: Recruiting
  • Study Type: Biological
  • Participants: 20
  • Start Date: September 16, 2020
Human Amniotic Epithelial Stem Cell in Treatment of Refractory Severe Intrauterine Adhesion