PROPULSION SANTE: Inflammometry to Improve the Diagnostic Trajectory in Situations of Suspected Asthma in Children and Adults

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

The objective of this observational study is to assess the relevance of inflammometry (based on the measurement of fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC)) as a tool for prioritizing respiratory diagnostic tests. The study will evaluate the role of inflammometry (FeNO and BEC) in prioritizing diagnostic respiratory tests. It will include patients aged six and older with suspected asthma, referred by non-pulmonologists for diagnostic asthma testing (spirometry or methacholine challenge test) at three hospital centers: Sherbrooke University Hospital Center (CHUS), Sainte-Justine University Hospital Center (CHU Sainte-Justine), and the Montreal Children's Hospital. The hypothesis is that using inflammometry as a prioritization tool would reduce diagnostic delays for high-risk patients with elevated biomarkers. This study could help shorten wait times, relieve congestion in diagnostic testing queues, and improve the diagnostic pathway. Additionally, it would enhance the interpretation of pulmonary function test results by incorporating inflammometry findings, leading to better patient stratification. Patients referred from primary care will undergo pulmonary function testing (spirometry ± methacholine challenge) and, as part of the study: FeNO measurement using a portable device Blood test for eosinophil count Questionnaire on asthma control and quality of life, completed at the visit and at follow-ups at 4, 8, and 12 months

Eligibility
Participation Requirements
Sex: All
Minimum Age: 6
Healthy Volunteers: f
View:

• patients age 6 and older

• referred by primary care ofr an asthma diagnostic test (spirometry or methacholine challenge)

Locations
Other Locations
Canada
CHU Sainte-Justine
NOT_YET_RECRUITING
Montreal
Montreal Children's Hospital
NOT_YET_RECRUITING
Montreal
CIUSSS de l'Estrie - CHUS
RECRUITING
Sherbrooke
Contact Information
Primary
Simon Couillard, MD, MSc
s.couillard@usherbrooke.ca
+1-819-346-1110
Time Frame
Start Date: 2025-03-24
Estimated Completion Date: 2027-07-01
Participants
Target number of participants: 1500
Treatments
Patients aged ≥6 years awaiting respiratory function tests requested by primary care
People aged ≥6 years waiting for their respiratory test will be invited to a clinical appointment and offered additional evaluation as part of this study, including : 1/ medical history 2/ exhaled fraction of nitric oxide FeNO measurement (using a portable NIOX VERO device) 3/ a blood test to measure blood eosinophil count (BEC) 4/Questionnaires to be completed on quality of life and asthma control, as well as satisfaction forms.
Related Therapeutic Areas
Sponsors
Collaborators: Fonds recherche du Québec Santé, AstraZeneca, Niox Group Plc, Ministere de la Sante et des Services Sociaux, Association Pulmonaire du Quebec
Leads: Université de Sherbrooke

This content was sourced from clinicaltrials.gov