RISKA: Respiratory Irritability With School Kids With/Without Asthma - Assessment of Methacholine Responsiveness in Pediatric Asthma: A Comparative Study With Healthy Controls
The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.
• • Aged 7-15 years, both sexes
‣ No diagnosis of asthma in childhood
⁃ No inhaled asthma medication during the previous 2 years
⁃ No wheezing or shortness of breath during the previous 2 years
⁃ Written informed consent from the participant and guardian
• Aged 7-15 years, both sexes
• Physician-diagnosed asthma (ICD-10 codes J45.0/J45.1/J45.9)
• Inhaled corticosteroid treatment for at least 6 months
• Either:
‣ Well-controlled asthma (c-ACT/ACT score ≥20) and no clinical need to intensify medication, or
⁃ Poorly controlled asthma with physician-confirmed need for intensified asthma medication