Standardized Transcutaneous Oxygen Pressure Determination in the Upper Limb: Normal Value and Chronic Limb Ischemia

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Upper limb arterial disease is a rare condition compared to lower limb arterial disease. In the lower limb, chronic limb ischemia (CLI) is characterized by an intractable pain or an ulceration present for at least 2 weeks. Guidelines recommend to use Transcutaneous Oxygen pressure (TcPO2) measurement when a CLI is suspected to establish diagnostic with a threshold of 30 mmHg when ankle and toe systolic pressure are not available. In the upper limb, there is no guideline to define CLI. When there is a wound preventing finger pressure measurement, TcPO2 is theoretically indicated. However, there is neither standardized site to measure nor threshold value of TcPO2. The investigators hypothesized that normal TcPO2 may be different in the upper limb and that threshold value for CLI may also be different compared to lower limb. The investigators planned a study with two parts: 1. Prospective study of normal TcPO2 value in healthy volunteers 2. Retrospective analysis of patients with upper limb arterial disease to approach the TcPO2 threshold of CLI allowing healing in upper limb

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• healthy volunteer without upper limb arterial disease

• absence of opposition

• affiliated to social insurance

• patients with a TCPO2 measurement available for the upper limb

• patients with a follow-up of at least 3 months available

• absence of opposition

• affiliated to social insurance

Locations
Other Locations
France
Service de Médecine Interne - UF Explorations Fonctionnelles Vasculaires, Hôpital Edouard Herriot
RECRUITING
Lyon
Contact Information
Primary
Judith CATELLA, MD
Judith.catella@chu-lyon.fr
+33 472 11 77 91
Backup
Evelyne DECULLIER, MD
evelyne.decullier@chu-lyon.fr
04 72 11 57 06
Time Frame
Start Date: 2022-03-01
Estimated Completion Date: 2026-09
Participants
Target number of participants: 60
Treatments
Healthy Volunteers
TcPO2 measurement in the upper limb of healthy volunteers
Patients with arterial disease in the upper limb and wound
Patients with arterial disease in the upper limb and wound (retrospective setting, research on data)
Sponsors
Leads: Hospices Civils de Lyon

This content was sourced from clinicaltrials.gov

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