Peripheral Artery Disease
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Peripheral Artery Disease Overview

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Learn About Peripheral Artery Disease

What is the definition of Peripheral Artery Disease?
Peripheral artery disease is a condition in which the blood flow to the limbs is reduced due to a narrowing or blockage of the arteries. This narrowing of the arteries is usually caused by fatty buildup (plaque) called atherosclerosis. Peripheral artery disease more commonly affects the legs but may also occur in the arms.
What are the symptoms of Peripheral Artery Disease?
Peripheral artery disease may not have any symptoms or only mild symptoms. The most common symptoms of peripheral artery disease are mild-to-severe leg pain or cramping (claudication). Claudication is most often felt in the calf upon walking or climbing stairs and stops when at rest. Other symptoms of peripheral artery disease include cramping in one or both hips; leg numbness or weakness; cold lower legs and feet; sores or ulcerations on legs, feet, or toes that won’t heal; a bluish or grayish limb skin color; leg muscle wasting; slow hair growth or hair loss on legs; slow toenail growth; weak or absent pulse in legs or feet; pain when using arms such as when writing or doing manual work; and erectile dysfunction in men. Severe peripheral artery disease may also cause pain at rest and interrupt sleep.
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What are the current treatments for Peripheral Artery Disease?
Early peripheral artery disease can often be treated with exercise, a healthy diet, and quitting smoking. Treatment for more advanced peripheral artery disease is focused on managing pain and stopping atherosclerosis to prevent blood clots, heart attack, and stroke. Treatments for peripheral artery disease include regular exercise and medications, such as cholesterol-lowering drugs (statins); blood pressure-lowering drugs; blood sugar-lowering drugs; anticoagulant drugs to prevent blood clots, such as aspirin and Plavix; and drugs that increase blood flow to the limbs, such as cilostazol or pentoxifylline. Treatments for peripheral artery disease that is causing claudication include angioplasty, in which a catheter is inserted with a stent to reopen an artery and increase blood flow; and bypass surgery, in which an artery taken from another area of the body, or a synthetic vessel, is grafted around a blocked artery. Thrombolytic therapy, in which a clot-dissolving drug is injected into a blocked artery, may also be used to treat peripheral artery disease that has caused blood clots.
Who are the top Peripheral Artery Disease Local Doctors?
Elite in Peripheral Artery Disease
Elite in Peripheral Artery Disease
Referral may be required

Duke Cardiology Arringdon

5601 Arringdon Park Dr, 
Morrisville, NC 
919-997-3100
Languages Spoken:
English, Gujarati 
See accepted insurances
Accepting New Patients
Offers Telehealth

Manesh Patel is a Cardiologist practicing medicine in Morrisville, North Carolina. Dr. Patel is rated as an Elite provider by MediFind in the treatment of Peripheral Artery Disease. He is also highly rated in 25 other conditions, according to our data. His clinical expertise encompasses Peripheral Artery Disease, Atherosclerosis, Coronary Heart Disease, Percutaneous Coronary Intervention (PCI), and Angioplasty. Dr. Patel is board certified in American Board Of Internal Med, Interventional Cardiology and American Board Of Internal Med, Cardiovascular Disease . Dr. Patel is currently accepting new patients.

Elite in Peripheral Artery Disease
Dr. Vikram S. Kashyap
Vascular Surgery
Elite in Peripheral Artery Disease
Dr. Vikram S. Kashyap
Vascular Surgery
Referral may be required

Corewell Health Vascular Surgery - 275 Michigan St NE

275 Michigan Street Northeast, 
Grand Rapids, MI 
616-267-8700
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Vikram Kashyap is a Vascular Surgeon practicing medicine in Grand Rapids, Michigan. Dr. Kashyap is rated as an Elite provider by MediFind in the treatment of Peripheral Artery Disease. He is also highly rated in 16 other conditions, according to our data. His clinical expertise encompasses Carotid Artery Disease, Peripheral Artery Disease, Thoracic Aortic Aneurysm, Carotid Artery Surgery, and Stent Placement. Dr. Kashyap is board certified in American Board Of Surgery. Dr. Kashyap is currently accepting new patients.

 
 
 
 
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Elite in Peripheral Artery Disease
Elite in Peripheral Artery Disease
Referral may be required

University Hospitals

11100 Euclid Ave, 
Cleveland,, OH 
216-844-1000
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Mehdi Shishehbor is a Cardiologist practicing medicine in Cleveland,, Ohio. Dr. Shishehbor is rated as an Elite provider by MediFind in the treatment of Peripheral Artery Disease. He is also highly rated in 17 other conditions, according to our data. His clinical expertise encompasses Peripheral Artery Disease, Atherosclerosis, Arterial Insufficiency, Angioplasty, and Atherectomy. Dr. Shishehbor is currently accepting new patients.

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What are the latest Peripheral Artery Disease Clinical Trials?
A Study to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants With Peripheral Artery Disease: A Randomized, Double-Blind, Placebo Controlled Trial
A Study to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants With Peripheral Artery Disease: A Randomized, Double-Blind, Placebo Controlled Trial
Enrollment Status: Recruiting
Publish Date: September 08, 2026
Intervention Type: Drug
Study Phase: Phase 3

Summary: The purpose of this study is to evaluate the effect and safety of orforglipron once daily in participants with Fontaine II peripheral arterial disease (PAD). Participation in the study will last about 58 weeks.

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Optimal Strategy for Treatment of Atherosclerotic Cardiovascular Disease - Comparison of Clopidogrel-based Antiplatelet Agent Treatment Versus Aspirin Plus Low Dose Rivaroxaban Therapy
Optimal Strategy for Treatment of Atherosclerotic Cardiovascular Disease - Comparison of Clopidogrel-based Antiplatelet Agent Treatment Versus Aspirin Plus Low Dose Rivaroxaban Therapy
Enrollment Status: Recruiting
Publish Date: September 02, 2026
Intervention Type: Drug
Study Phase: Phase 4

Summary: The study aims to conduct a randomized controlled trial among adults aged 19 years or older who have experienced acute myocardial infarction at least one year prior, or who have other comorbidities such as peripheral arterial disease or multiple cardiovascular diseases, and have consented to participate in the study. Participants will be randomly assigned to either a group that maintains antiplate...

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