Carnosine for Peripheral Arterial Disease Patients (Car-PAD)
Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY
Oral supplementation of L-carnosine will increase muscle carnosine, stabilize HIF1-alpha promote angiogenesis, and thus improve the functioning of lower extremities in PAD patients.
Eligibility
Participation Requirements
Sex: Male
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: f
View:
• Male subjects more than \>50 to \<80 years of age.
• White or African American race.
• English Speaking.
• ABI 0.4-\< 0.60
• Willing to comply with protocol requirements.
• Able to provide informed consent. -
Locations
United States
Kentucky
University of Louisville
RECRUITING
Louisville
Time Frame
Start Date: 2023-03-01
Estimated Completion Date: 2024-12-30
Participants
Target number of participants: 20
Treatments
Experimental: Carnosine intervention for patients with PAD
This is a single arm open labelled safety trial, where we will supplement carnosine for 3 months to subjects with non-claudication and claudication peripheral arterial disease (PAD), and determine if it improves walking ability.
Related Therapeutic Areas
Sponsors
Leads: Shahid Baba