Peripheral Artery Disease: Gated P-31 Magnetic Resonance Spectroscopy in Functional Assessment of Peripheral Artery Disease (spectroAMI)
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY
To explore the reliability of P-31 MR spectroscopy mitochondrial function in patients with peripheral arterial occlusive disease.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Peripheral arterial occlusive disease (PAOD) with claudication and surgery planning with proximal lesion (iliac or femoral (x-ray angiography or CT or MRA) and no distal lesions (doppler)
• ABI\<0.90 or \>1.30
• signed consent form
• health insurance coverage
Locations
Other Locations
France
Chu Saint-Etienne
RECRUITING
Saint-etienne
Contact Information
Primary
Pierre CROISILLE, PhD
croisille@creatis.insa-lyon.fr
(0)477127584
Time Frame
Start Date: 2019-02-13
Estimated Completion Date: 2025-04
Participants
Target number of participants: 40
Treatments
PAOD patients statin (+)
Patients with Peripheral Arterial Occlusive Disease (PAOD) and statin treatment.~They will have Magnetic Resonance Imaging (MRI; muscular volume and composition) and gated-P-31 magnetic resonance spectroscopy (MRS) with low-intensity ergometric exercise. It will be performed before surgery (within 48h) and after surgery (first week)
PAOD patients statin (-)
Patients with Peripheral Arterial Occlusive Disease (PAOD) without statin treatment .~They will have Magnetic Resonance Imaging (MRI ; muscular volume and composition) and gated-P-31 magnetic resonance spectroscopy (MRS) with low-intensity ergometric exercise. It will be performed before surgery (within 48h) and after surgery (first week)
Related Therapeutic Areas
Sponsors
Collaborators: Dr SLADE Jill M. Department of Osteopathic Manipulative Medicine, Michigan State University, Dr MAYER Ronald A. Department of Physiology, Michigan State University
Leads: Centre Hospitalier Universitaire de Saint Etienne