Maternal and Offspring Outcomes in Pregnant Women With Pre-existing Atherosclerotic Cardiovascular Disease: A Nationwide Mother-Child Cohort Study
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
A growing body of evidence supports associations between cardiovascular health and adverse pregnancy outcome and between adverse pregnancy outcome and atherosclerotic cardiovascular disease and builds on the well-established pathways known to exist between cardiovascular health and atherosclerotic cardiovascular disease across the life course and intergenerationally. Furthermore, previous studies frequently lack comprehensive long-term follow-up, making it difficult to assess the enduring impacts of maternal cardiovascular health on postpartum outcomes and long-term maternal and child health.
Eligibility
Participation Requirements
Sex: Female
View:
• Women with live birth from Korea (between January 1, 2005 to December 31, 2019)
Locations
Other Locations
Republic of Korea
Samsung Medical Center
RECRUITING
Seoul
Contact Information
Primary
Ki Hong Choi
cardiokh@gmail.com
82-2-3410-3419
Backup
Danbee Kang, PhD
dbee.kang@skku.edu
82-2-2148-7197
Time Frame
Start Date: 2021-01-01
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 5461222
Treatments
Pregnant women with pre-existing atherosclerotic cardiovascular disease
Among the total cohort, pregnant women with pre-existing atherosclerotic cardiovascular disease were selected (N=145,315).
Matched cohort
Among the total cohort, 1:4 matched offspring born to women without pre-existent atherosclerotic cardiovascular disease using a propensity score were generated (N=581,260).
Related Therapeutic Areas
Sponsors
Leads: Samsung Medical Center