Vascular Regenerative Cell Exhaustion in Adults with Peripheral Artery Disease
PAD-VRCE is an observational, cross-sectional, two arm study aimed at determining if the presence of peripheral artery disease (PAD) can influence the number of circulating regenerative cells in blood. From peripheral blood samples, circulating progenitor cell content will be assessed via flow cytometry and compared between individuals with PAD and individuals without PAD. Ultimately, this study plans to evaluate the relationship between PAD, vascular regenerative cell exhaustion and overall cardiovascular health.
• Adults ≥18 and ≤80 years of age who meet either of the following criteria:
‣ Clinically significant/symptomatic PAD (defined as symptomatic claudication with and an ankle brachial index of less than 0.85).
⁃ No history of PAD.
• Willing and able to provide written informed consent and comply with study procedures.