Unraveling the Potential of Physical Activity in the Treatment of Familial Hypercholesterolemia: Impact of Exercise on Cardiorespiratory Fitness, Atherosclerosis Progression, and Underlying Mechanisms
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study has one main objective: a) To assess the impact of two different supervised exercise interventions on cardiorespiratory fitness and markers of subclinical atherosclerosis in patients with Familiar Hipercolesterolemia (FH), and to unravel the underlying mechanisms behind these effects. The starting hypothesis of the UPPA-FH project anticipates that both exercise interventions will produce a large increase in cardiorespiratory fitness and will improve significant markers of atherosclerosis in patients with FH, with high-intensity interval training program (HIIT) being more efficient than the moderate-intensity continuous training (MICT) modality. The main effects will be mediated by a significant change in the metabolomic signature of the participants. In addition, higher physical activity will be associated with more favorable markers of atherosclerosis progression, as shown through blood and image technique
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Individuals with a diagnosis of genetic FH.
• \> 18 years old.
• Minimum follow-up of 1 year in the Vascular Risk Clinic of the Virgen de las Nieves University Hospital (HUVN).
• Clinical and treatment stability.
• Non-pathological angio-TAC of coronary arteries in the 2 years prior to the study (for participants \>45 years old).
Locations
Other Locations
Spain
Virgen de las Nieves University Hospital
RECRUITING
Granada
Contact Information
Primary
Jose A Vargas-Hitos, MD, PHD
joseantoniovh@hotmail.com
+34625943933
Backup
Alberto Soriano-Maldonado, PHD
asoriano@ual.es
Time Frame
Start Date:2025-02-20
Estimated Completion Date:2027-07-31
Participants
Target number of participants:75
Treatments
Experimental: High Intensity Interval Training (HIIT) intervention program
The HIIT protocol will involve 3 training sessions per week for 16 weeks (a total of 48 sessions lasting 36 minutes). The high-intensity intervals will follow the Norwegian 4 x 4-minute HIIT model: 4 bouts of 4 minutes of high intensity corresponding to a rating of perceived exertion (RPE) 15 to 18 on the Borg 6 to 20 Scale and an 85-95%HRmax, interspersed with 3-minute active recovery intervals (RPE of 11 to 13 and 54-69%HRmax).
Experimental: Moderate Intensity Continous Training (MICT) intervention program
The MICT protocol will involve 3 training sessions per week for 16 weeks (a total of 48 sessions lasting 44 minutes). The workout will be performed at RPE 11 to 13 (54-69%HRmax) to provide an isoenergetic workload (same energy expenditure) as the HIIT group
No_intervention: Control group
The control group will follow a usual care regime during the intervention and will not participate in supervised exercise. However, the participants randomized to this group will be invited to participate in a similar intervention once the study is completed (waiting list control group).