Familial Hypercholesterolemia
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Familial Hypercholesterolemia Overview

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Learn About Familial Hypercholesterolemia

View Main Condition: High Cholesterol

What is the definition of Familial Hypercholesterolemia?
Familial hypercholesterolemia is a common genetic condition that causes high blood levels of low-density lipoprotein (LDL), or bad, cholesterol. This bad cholesterol builds up in the arteries, causing them to harden and narrow. Familial hypercholesterolemia increases the risks of cardiovascular disease and heart attack.
What are the symptoms of Familial Hypercholesterolemia?
Symptoms of familial hypercholesterolemia may not occur until an adult. If an individual inherits familial hypercholesterolemia from both parents, symptoms usually appear in childhood. Symptoms of familial hypercholesterolemia may include xanthelasmas (cholesterol lesions in the eyelids); a white or gray ring around the iris of the eye; xanthomas (fatty skin lesions) around the cornea and on the hands, elbows, buttocks, knees, and ankles; chest pain; stroke-like symptoms, such as speech difficulties, facial paralysis, arm or leg weakness, and loss of balance; calve cramping upon walking; cholesterol deposits in tendons; sores on toes; cerebrovascular disease; peripheral artery disease; transient ischemic attack; and stroke.
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What are the current treatments for Familial Hypercholesterolemia?
Familial hypercholesterolemia in childhood that is left untreated can lead to death by age 20. However, the cardiovascular symptoms associated with familial hypercholesterolemia can be prevented with early treatment. Treatments for familial hypercholesterolemia include lifestyle modifications, such as a low-saturated fat diet, weight loss, and regular exercise; quitting smoking; medications, such as atorvastatin, Fluvastatin, lovastatin, pravastatin, pitivastatin, rosuvastatin, simvastatin, colesevalam, Welcol, bempedoic acid, icosapent ethyl, ezetimibe, fibrates, nicotinic acid, alirocumab, evinacumab-dgnb, evolocumab, lomitapide, and mipomersen; blood plasma-filtering (apharesis); and liver transplantation.
Who are the top Familial Hypercholesterolemia Local Doctors?
Elite in Familial Hypercholesterolemia
Dr. Zahid Ahmad
Endocrinology
Elite in Familial Hypercholesterolemia
Dr. Zahid Ahmad
Endocrinology
Referral may be required

University Of Texas Southwestern Medical Center

5323 Harry Hines Blvd, 
Dallas, TX 
214-590-8058
Languages Spoken:
English
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Offers Telehealth

Zahid Ahmad is an Endocrinologist practicing medicine in Dallas, Texas. Dr. Ahmad is rated as an Elite provider by MediFind in the treatment of Familial Hypercholesterolemia. He is also highly rated in 7 other conditions, according to our data. His clinical expertise encompasses Familial Hypercholesterolemia, Familial Hypertriglyceridemia, Defective Apolipoprotein B-100, and Heterozygous Familial Hypercholesterolemia (HeFH).

Elite in Familial Hypercholesterolemia
Dr. Paul Duell
Endocrinology
Elite in Familial Hypercholesterolemia
Dr. Paul Duell
Endocrinology
Referral may be required

OHSU Hospital

3181 SW Sam Jackson Park Rd, 
Portland, OR 
503-494-3273
Languages Spoken:
English
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Offers Telehealth

Paul Duell is an Endocrinologist practicing medicine in Portland, Oregon. Dr. Duell is rated as an Elite provider by MediFind in the treatment of Familial Hypercholesterolemia. He is also highly rated in 9 other conditions, according to our data. His clinical expertise encompasses Familial Hypercholesterolemia, Defective Apolipoprotein B-100, Homozygous Familial Hypercholesterolemia (HoFH), and Heterozygous Familial Hypercholesterolemia (HeFH).

 
 
 
 
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Elite in Familial Hypercholesterolemia
Dr. Macrae Linton
Internal Medicine
Elite in Familial Hypercholesterolemia
Dr. Macrae Linton
Internal Medicine

Vanderbilt Heart One Hundred Oaks

719 Thompson Ln Ste 22100, 
Nashville, TN 
615-322-5000
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Macrae Linton is an Internal Medicine provider practicing medicine in Nashville, Tennessee. Dr. Linton is rated as an Elite provider by MediFind in the treatment of Familial Hypercholesterolemia. He is also highly rated in 9 other conditions, according to our data. His clinical expertise encompasses High Cholesterol, Atherosclerosis, Familial Hypercholesterolemia, Familial Hypertriglyceridemia, and Nephrectomy.

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What are the latest Familial Hypercholesterolemia Clinical Trials?
Phase 3 Study to Evaluate the Efficacy and Safety of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)
Phase 3 Study to Evaluate the Efficacy and Safety of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)
Enrollment Status: Recruiting
Publish Date: June 10, 2026
Intervention Type: Drug
Study Phase: Phase 3

Summary: This multicenter, randomized, placebo-controlled study will evaluate the efficacy and safety of zodasiran subcutaneous (SC) injection in subjects 12 years of age and older with genetically or clinically diagnosed Homozygous familial hypercholesterolemia (HoFH). After completion of the double blind (DB) treatment period subjects will be eligible to continue in the optional open-label extension (OLE...

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Open-label, Phase 1b, Single Ascending Dose Study to Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia or Premature Coronary Artery Disease Who Require Additional Lowering of Low-density Lipoprotein Cholesterol
Open-label, Phase 1b, Single Ascending Dose Study to Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia or Premature Coronary Artery Disease Who Require Additional Lowering of Low-density Lipoprotein Cholesterol
Enrollment Status: Recruiting
Publish Date: June 02, 2026
Intervention Type: Drug
Study Phase: Phase 1

Summary: VT-10201 is an Open-label, Phase 1b, Single-ascending Dose Study That Will Evaluate the Safety of VERVE-102 Administered to Patients With Heterozygous Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Base-editing Technology Designed to Disrupt the Expression of the PCSK9 Gene in the Liver and Lower Circulating ...

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